ArticleNature communications2016
Protein unfolding as a switch from self-recognition to high-affinity client binding.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Switchable client specificity in a dual functional chaperone coordinates light-harvesting complex biogenesis.Science advances · 2025Article
- Roles of Nucleic Acids in Protein Folding, Aggregation, and Disease.ACS chemical biology · 2024Review
- The cold atmospheric pressure plasma-generated species superoxide, singlet oxygen and atomic oxygen activate the molecular chaperone Hsp33.Journal of the Royal Society, Interface · 2023Article
- HslO ameliorates arrested ΔrecA polA cell growth and reduces DNA damage and oxidative stress responses.Scientific reports · 2022Article
- Vitamin C Maintenance against Cell Growth Arrest and Reactive Oxygen Species Accumulation in the Presence of Redox Molecular ChaperoneInternational journal of molecular sciences · 2022Article
- Article
- Review
- Fort CnoX: Protecting Bacterial Proteins From Misfolding and Oxidative Damage.Frontiers in molecular biosciences · 2021Review
- Article
- The Anti-Aggregation Holdase Hsp33 Promotes the Formation of Folded Protein Structures.Biophysical journal · 2020Article
- TrypOx, a Novel Eukaryotic Homolog of the Redox-Regulated Chaperone Hsp33 inFrontiers in microbiology · 2020Article
- Protein folding while chaperone bound is dependent on weak interactions.Nature communications · 2019Article
- Local unfolding of the HSP27 monomer regulates chaperone activity.Nature communications · 2019Article
- Chaperone activation and client binding of a 2-cysteine peroxiredoxin.Nature communications · 2019Article
- Stress-induced chaperones: a first line of defense against the powerful oxidant hypochlorous acid.F1000Research · 2019Review
- Sialic acid involves in the interaction between ovomucin and hemagglutinin and influences the antiviral activity of ovomucin.International journal of biological macromolecules · 2018Article
- Mechanical properties of BiP protein determined by nano-rheology.Protein science : a publication of the Protein Society · 2018Article
- Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry.Journal of visualized experiments : JoVE · 2018Article
- A switch point in the molecular chaperone Hsp90 responding to client interaction.Nature communications · 2018Article
- Maintaining a Healthy Proteome during Oxidative Stress.Molecular cell · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Stress-specific activation of the chaperone Hsp33 requires the unfolding of a central linker region. This activation mechanism suggests an intriguing functional relationship between the chaperone's own partial unfolding and its ability to bind other partially folded client proteins. However, identifying where Hsp33 binds its clients has remained a major gap in our understanding of Hsp33's working mechanism. By using site-specific Fluorine-19 nuclear magnetic resonance experiments guided by in vivo crosslinking studies, we now reveal that the partial unfolding of Hsp33's linker region facilitates client binding to an amphipathic docking surface on Hsp33. Furthermore, our results provide experimental evidence for the direct involvement of conditionally disordered regions in unfolded protein binding. The observed structural similarities between Hsp33's own metastable linker region and client proteins present a possible model for how Hsp33 uses protein unfolding as a switch from self-recognition to high-affinity client binding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.