Observational studyThe Journal of pediatrics2016
Clinical Features, Virus Identification, and Sinusitis as a Complication of Upper Respiratory Tract Illness in Children Ages 4-7 Years.
Observational study in The Journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- The rs6967330 minor allele in CDHR3 is a significant risk factor for severe acute exacerbations in chronic rhinosinusitis.The Journal of allergy and clinical immunology · 2025Article
- Indoor allergen exposure and its association to upper respiratory infections and pulmonary outcomes among children with asthma.The Journal of allergy and clinical immunology · 2024Article
- Tonsillitis and Sinusitis: A Narrative Review of Pathogenesis, Diagnosis, and Management.Cureus · 2023Review
- Genotypic Diversity of Childhood Rhinovirus Infections.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Pre-Visit Use of Non-Prescribed Antibiotics among Child Patients in China: Prevalence, Predictors, and Association with Physicians' Prescribing of Antibiotics at Medical Visits.Antibiotics (Basel, Switzerland) · 2022Article
- Wisconsin Upper Respiratory Symptom Survey for Kids: Validation of an Illness-specific Quality of Life Instrument.Pediatric research · 2021Article
- Paranasal sinusitis at the initiation of chemotherapy is a risk factor for invasive fungal disease in children and adolescents with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Microbiology of Acute Maxillary Sinusitis in Children.The Laryngoscope · 2021Article
- Moraxella-dominated pediatric nasopharyngeal microbiota associate with upper respiratory infection and sinusitis.PloS one · 2021Article
- Viral Coinfection and Nasal Cytokines in Children With Clinically Diagnosed Acute Sinusitis.Frontiers in pediatrics · 2021Article
- Acute bacterial sinusitis in children: an updated review.Drugs in context · 2020Review
- Clinical and Virological Characteristics of Acute Sinusitis in Children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Antibiotic Recommendations for Acute Otitis Media and Acute Bacterial Sinusitis: Conundrum No More.The Pediatric infectious disease journal · 2018Article
- Early life risk factors for chronic sinusitis: A longitudinal birth cohort study.The Journal of allergy and clinical immunology · 2018Article
- Dynamics of Bacterial Colonization With Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis During Symptomatic and Asymptomatic Viral Upper Respiratory Tract Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Observational
- Natural therapeutic approach ofIntegrative medicine research · 2018Review
- Diagnostic performance and clinical feasibility of a point-of-care test for respiratory viral infections in primary health care.Family practice · 2017Article
- Dual RNA-seq reveals viral infections in asthmatic children without respiratory illness which are associated with changes in the airway transcriptome.Genome biology · 2017Article
- How to avoid the inappropriate use of antibiotics in upper respiratory tract infections? A position statement from an expert panel.Brazilian journal of otorhinolaryngologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine the rate of sinusitis complicating upper respiratory tract illnesses (URIs) in children. We prospectively identified the clinical, virologic, and epidemiologic characteristics of URIs in a population of 4- to 7-year-old children followed for 1 year. STUDY
designThis was an observational cohort study in 2 primary care pediatric practices in Madison, Wisconsin. Nasal samples were obtained during 4 asymptomatic surveillance visits and during symptomatic URIs. A polymerase chain reaction-based assay for 9 respiratory viruses was performed on nasal samples. A diagnosis of sinusitis was based on published criteria.
resultsTwo hundred thirty-six children ages 48-96 months were enrolled. A total of 327 URIs were characterized. The mean number of URIs per child was 1.3 (range 0-9) per year. Viruses were detected in 81% of URIs; rhinovirus (RV) was most common. Seventy-two percent of URIs were resolved clinically by the 10th day. RV-A and RV-C were detected more frequently at URI visits; RV-B was detected at the same rate for both asymptomatic surveillance visits and URI visits. Sinusitis was diagnosed in 8.8% of symptomatic URIs. Viruses were detected frequently (33%) in samples from asymptomatic children.
conclusionsSinusitis occurred in 8.8% of symptomatic URIs in our study. The virus most frequently detected with URIs in children was RV; RV-A and RV-C detection but not RV-B detection were associated with illness. Viruses, especially RV, are detected frequently in asymptomatic children. Most URIs have improved or resolved by the 10th day after onset. Children experienced a mean of 1.3 URIs per year, which was lower than expected.
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Registered trials
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