ArticleHuman brain mapping2016
Disrupted white matter connectivity underlying developmental dyslexia: A machine learning approach.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 178 citations in OpenAlex.
- Evaluation of Risk of Bias in Neuroimaging-Based Artificial Intelligence Models for Psychiatric Diagnosis: A Systematic Review.JAMA network open · 2023Pooled it
- Somatosensory Deficits After Stroke: Insights From MRI Studies.Frontiers in neurology · 2022Pooled it
- White matter tract microstructure of the mPFC-amygdala predicts interindividual differences in placebo response related to treatment in migraine patients.Human brain mapping · 2019Trial
- Functional Brain Network Predictors of Abstinence Treatment Outcomes in Methamphetamine Use Disorder.CNS neuroscience & therapeutics · 2026Article
- Mapping trait justice sensitivity in the Brain: Whole-brain resting-state functional connectivity as a predictor of other-oriented not self-oriented justice sensitivity.Cognitive, affective & behavioral neuroscience · 2025Article
- [The application of machine learning in the auxiliary diagnosis of specific learning disorder].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Review
- Multimodal investigation of the neurocognitive deficits underlying dyslexia in adulthood.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Asymmetric Inter-Hemisphere Communication Contributes to Speech Acquisition of Toddlers with Cochlear Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Distinct connectivity patterns between perception and attention-related brain networks characterize dyslexia: Machine learning applied to resting-state fMRI.Cortex; a journal devoted to the study of the nervous system and behavior · 2024Article
- Hierarchical individual variation and socioeconomic impact on personalized functional network topography in children.BMC medicine · 2024Article
- A Review of Artificial Intelligence-Based Dyslexia Detection Techniques.Diagnostics (Basel, Switzerland) · 2024Review
- Assessing Language Lateralization through Gray Matter Volume: Implications for Preoperative Planning in Brain Tumor Surgery.Brain sciences · 2024Article
- Genetic Variants Linked to Dyslexia Co-Morbid ADHD: A Case Study of a Pakistani Outpatient.Journal of population therapeutics and clinical pharmacology = Journal de la therapeutique des populations et de la pharmacologie clinique · 2024Article
- Functional connectome through the human life span.bioRxiv : the preprint server for biology · 2024Article
- Exploring brain plasticity in developmental dyslexia through implicit sequence learning.NPJ science of learning · 2024Article
- White matter microstructural plasticity associated with educational intervention in reading disability.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- From brain to education through machine learning: Predicting literacy and numeracy skills from neuroimaging data.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Brain multi-contrast, multi-atlas segmentation of diffusion tensor imaging and ensemble learning automatically diagnose late-life depression.Scientific reports · 2023Article
- Properties of white matter tract diffusivity in children with developmental dyslexia and comorbid attention deficit/hyperactivity disorder.Journal of neurodevelopmental disorders · 2023Article
- A single case neuroimaging study of tickertape synesthesia.Scientific reports · 2023Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Developmental dyslexia has been hypothesized to result from multiple causes and exhibit multiple manifestations, implying a distributed multidimensional effect on human brain. The disruption of specific white-matter (WM) tracts/regions has been observed in dyslexic children. However, it remains unknown if developmental dyslexia affects the human brain WM in a multidimensional manner. Being a natural tool for evaluating this hypothesis, the multivariate machine learning approach was applied in this study to compare 28 school-aged dyslexic children with 33 age-matched controls. Structural magnetic resonance imaging (MRI) and diffusion tensor imaging were acquired to extract five multitype WM features at a regional level: white matter volume, fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity. A linear support vector machine (LSVM) classifier achieved an accuracy of 83.61% using these MRI features to distinguish dyslexic children from controls. Notably, the most discriminative features that contributed to the classification were primarily associated with WM regions within the putative reading network/system (e.g., the superior longitudinal fasciculus, inferior fronto-occipital fasciculus, thalamocortical projections, and corpus callosum), the limbic system (e.g., the cingulum and fornix), and the motor system (e.g., the cerebellar peduncle, corona radiata, and corticospinal tract). These results were well replicated using a logistic regression classifier. These findings provided direct evidence supporting a multidimensional effect of developmental dyslexia on WM connectivity of human brain, and highlighted the involvement of WM tracts/regions beyond the well-recognized reading system in dyslexia. Finally, the discriminating results demonstrated a potential of WM neuroimaging features as imaging markers for identifying dyslexic individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.