ArticleNature communications2016
Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Distinct transcription factor network dynamics underlie early and long-term adaptation to rifampicin inmSystems · 2026Article
- Characterization of KPC-160, a novel Ω-loop-deleted KPC variant on a dual-copy plasmid that confers cefiderocol resistance.Antimicrobial agents and chemotherapy · 2026Article
- Engineering oncolytic bacteria as precision cancer therapeutics: design principles, therapeutic strategies, and translational perspectives.Protein & cell · 2026Review
- Engineering smart bacteria for the next generation.Cell reports. Medicine · 2026Review
- A Natural Sweetener-inducible Genetic Switch Controls Therapeutic Protein Expression in Mammals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Engineered bacteria for near-infrared light-inducible expression of cancer therapeutics.Nature cancer · 2025Article
- The Persistence of Antibiotic Resistance in Observational Studies: Is It Really Due to Differences in Sub-Populations Rather than Antibiotic Use?Antibiotics (Basel, Switzerland) · 2025Article
- Prevalence of antibiotic resistance genes its association with microbiota in raw milk of northwest Xinjiang.Frontiers in microbiology · 2025Article
- Changes in oral, skin, and gut microbiota in children with atopic dermatitis: a case-control study.Frontiers in microbiology · 2024Article
- Engineering natural molecule-triggered genetic control systems for tunable gene- and cell-based therapies.Synthetic and systems biotechnology · 2023Article
- Lentiviral vectors for inducible, transactivator-free advanced therapy medicinal products: Application to CAR-T cells.Molecular therapy. Nucleic acids · 2023Article
- Antibiotic-Resistant Genes and Bacteria as Evolving Contaminants of Emerging Concerns (e-CEC): Is It Time to Include Evolution in Risk Assessment?Antibiotics (Basel, Switzerland) · 2021Article
- Review
- Ubiquitous selection for mecA in community-associated MRSA across diverse chemical environments.Nature communications · 2020Article
- Highly Contingent Phenotypes of Lon Protease Deficiency in Escherichia coli upon Antibiotic Challenge.Journal of bacteriology · 2020Article
- Prevalent Synergy and Antagonism Among Antibiotics and Biocides inFrontiers in microbiology · 2020Article
- Dead bacterial absorption of antimicrobial peptides underlies collective tolerance.Journal of the Royal Society, Interface · 2019Article
- Translating antibiotic prescribing into antibiotic resistance in the environment: A hazard characterisation case study.PloS one · 2019Article
- Metagenomic and Resistome Analysis of a Full-Scale Municipal Wastewater Treatment Plant in Singapore Containing Membrane Bioreactors.Frontiers in microbiology · 2019Article
- Efflux pump-mediated resistance to antifungal compounds can be prevented by conjugation with triphenylphosphonium cation.Nature communications · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Antibiotic-sensitive and -resistant bacteria coexist in natural environments with low, if detectable, antibiotic concentrations. Except possibly around localized antibiotic sources, where resistance can provide a strong advantage, bacterial fitness is dominated by stresses unaffected by resistance to the antibiotic. How do such mixed and heterogeneous conditions influence the selective advantage or disadvantage of antibiotic resistance? Here we find that sub-inhibitory levels of tetracyclines potentiate selection for or against tetracycline resistance around localized sources of almost any toxin or stress. Furthermore, certain stresses generate alternating rings of selection for and against resistance around a localized source of the antibiotic. In these conditions, localized antibiotic sources, even at high strengths, can actually produce a net selection against resistance to the antibiotic. Our results show that interactions between the effects of an antibiotic and other stresses in inhomogeneous environments can generate pervasive, complex patterns of selection both for and against antibiotic resistance.
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Registered trials
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