SynthesisSchmerz (Berlin, Germany)2016
Efficacy, tolerability, and safety of cannabinoids for chemotherapy-induced nausea and vomiting--a systematic review of systematic reviews.
Synthesis in Schmerz (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Is Percutaneous Adhesiolysis Effective in Managing Chronic Low Back and Lower Extremity Pain in Post-surgery Syndrome: a Systematic Review and Meta-analysis.Current pain and headache reports · 2020Pooled it
- Systematic review of systematic reviews for medical cannabinoids: Pain, nausea and vomiting, spasticity, and harms.Canadian family physician Medecin de famille canadien · 2018Pooled it
- Readiness to Use Medicinal Marijuana in the Practices of Polish Family Physicians.Journal of clinical medicine · 2026Article
- Cannabis, cannabinoids and health: a review of evidence on risks and medical benefits.European archives of psychiatry and clinical neuroscience · 2025Review
- Article
- Comparison of the Effect of Cumin Cyminum and Nettle Oral Drops on the Breast Milk Sufficiency Indicators in New Mothers.Sultan Qaboos University medical journal · 2024Article
- Oral Tetrahydrocannabinol (THC):Cannabinoid (CBD) Cannabis Extract Adjuvant for Reducing Chemotherapy-Induced Nausea and Vomiting (CINV): A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial.International journal of women's health · 2023Article
- Neurogenetic and Epigenetic Aspects of Cannabinoids.Epigenomes · 2022Article
- Association between cannabis use and physical health problems in Norwegian adolescents: a cross-sectional study from the youth survey Ungdata.BMC public health · 2022Article
- Routes of administration, reasons for use, and approved indications of medical cannabis in oncology: a scoping review.BMC cancer · 2022Article
- Gaps in evidence for the use of medically authorized cannabis: Ontario and Alberta, Canada.Harm reduction journal · 2021Article
- Antiemetic Effects of Cannabinoid Agonists in Nonhuman Primates.The Journal of pharmacology and experimental therapeutics · 2020Article
- Cannabinoids in the Older Person: A Literature Review.Geriatrics (Basel, Switzerland) · 2020Review
- Cancer Cachexia: Definition, Staging, and Emerging Treatments.Cancer management and research · 2020Review
- The Annual Meeting of the Thai Gynecologic Cancer Society 2019: Meeting report.Journal of gynecologic oncology · 2019Article
- Prospects for the Use of Cannabinoids in Oncology and Palliative Care Practice: A Review of the Evidence.Cancers · 2019Review
- [Chemotherapy-induced nausea and vomiting : Current recommendations for prophylaxis].Der Urologe. Ausg. A · 2018Review
- Leaner and greener analysis of cannabinoids.Analytical and bioanalytical chemistry · 2017Article
- Medical use of cannabis products: Lessons to be learned from Israel and Canada.Schmerz (Berlin, Germany) · 2016Article
- [Cannabis as a therapeutic agent: Focal topic].Schmerz (Berlin, Germany) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is growing public and legislative body support for the medical use of cannabis products, for example, for chemotherapy-induced nausea and vomiting (CINV), in Germany.
methodsA comprehensive literature search until November 2015 was conducted in MEDLINE, DARE and Cochrane libraries for systematic reviews of randomized controlled trials (RCTs) comparing herbal or pharmaceutical cannabinoids (CB) versus placebo or conventional antiemetics for CINV. Outcomes were reduction of CINV for efficacy, drop-out rates due to adverse events for tolerability, and serious adverse events for safety. The methodology quality of the systematic reviews was evaluated by the tool assessment of multiple systematic reviews (AMSTAR).
resultsSix systematic reviews of RCTs included the pharmaceutical CBs dronabinol, levonantradol, and nabilone or whole plant extract (e.g., nabiximol) compared with placebo or conventional antiemetics. There was moderate quality evidence on the efficacy of CBs compared to placebo and conventional antiemetics for CINV. There was moderate quality evidence that pharmaceutical CBs were less tolerated and less safe than placebo and conventional antiemetics in CINV. One RCT examining whole plant extract was included into the systematic reviews. No RCT was found comparing CBs with neurokinine-1 receptor antagonists.
conclusionsWith safe and effective antiemetics available, CBs cannot be recommended as first- or second-line therapy for CINV. Some guidelines recommend pharmaceutical CBs as third-line treatment in the management of breakthrough nausea and vomiting. Due to the lack of RCT data and safety concerns, herbal cannabis cannot be recommended for CINV.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.