SynthesisPhysiological genomics2016
Twin-sibling study and meta-analysis on the heritability of maximal oxygen consumption.
Synthesis in Physiological genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 4 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Polygenic scores and physical fitness prediction: a systematic review.Human genetics · 2026Pooled it
- Reviewing the association between motor competence and physical activity from a behavioral genetic perspective.Frontiers in psychology · 2025Pooled it
- The Genetic Profile of Combat Sport Athletes: A Systematic Review of Physiological, Psychological and Injury Risk Determinants.International journal of environmental research and public health · 2024Pooled it
- Do exercise-associated genes explain phenotypic variance in the three components of fitness? a systematic review & meta-analysis.PloS one · 2021Pooled it
- Trial
- Tai Chi Is a Promising Exercise Option for Patients With Coronary Heart Disease Declining Cardiac Rehabilitation.Journal of the American Heart Association · 2017Trial
- Guidelines for rigor and reproducibility of heart rate variability within human cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2026Review
- Cardiorespiratory fitness in adolescence and premature mortality: widespread bias identified using negative control outcomes and sibling comparisons.European journal of preventive cardiology · 2026Article
- Aerobic Exercise Response Variation and Cardiorespiratory Fitness in Adults with Coronary Heart Disease: An SDir Meta-Analysis of Randomized Controlled Trials.Journal of cardiovascular development and disease · 2026Review
- Brain resting state functional connectivity changes with aerobic exercise, and mindfulness: A narrative review.Sports medicine and health science · 2026Review
- Prognostic value of exercise blood pressure: role of fitness and exercise training.American journal of physiology. Heart and circulatory physiology · 2026Review
- Practical guidelines for exercise prescription in different clinical populations.Frontiers in sports and active living · 2026Review
- Article
- Epigenome-wide exploratory study of blood DNA methylation and markers of physical performance indicates subtle differences across levels of cardiovascular fitness.Frontiers in physiology · 2026Article
- Tracking of device-measured sedentary time, cardiorespiratory fitness, and cardiometabolic risk factors from childhood to young adulthood.American journal of preventive cardiology · 2025Article
- Integrative multi-omics uncovers skeletal muscle enhancer programming of cardiorespiratory fitness.bioRxiv : the preprint server for biology · 2025Article
- Overstated association between adolescent physical fitness and adulthood depression risk due to familial factors.Journal of internal medicine · 2025Article
- Fitness and Screen Time at Age 13 Relates to Academic Performance at Age 16.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Adolescent cardiorespiratory fitness and risk of cancer in late adulthood: A nationwide sibling-controlled cohort study in Sweden.PLoS medicine · 2025Article
- The MDM2 SNP309 differentially impacts cardiorespiratory fitness in young healthy women and men.European journal of applied physiology · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Large individual differences exist in aerobic fitness in childhood and adolescence, but the relative contribution of genetic factors to this variation remains to be established. In a sample of adolescent twins and siblings (n = 479), heart rate (HR) and maximal oxygen uptake (V̇o2max) were recorded during the climax of a graded maximal exercise test. In addition, V̇o2max was predicted in two graded submaximal exercise tests on the cycle ergometer and the treadmill, using extrapolation of the HR/V̇o2 curve to the predicted HRmax. Heritability estimates for measured V̇o2max were 60% in ml/min and 55% for V̇o2max in ml·min(-1)·kg(-1). Phenotypic correlations between measured V̇o2max and predicted V̇o2max from either submaximal treadmill or cycle ergometer tests were modest (0.57 < r < 0.70), in part because of the poor agreement between predicted and actual HRmax. The majority of this correlation was explained by genetic factors; therefore, the submaximal exercise tests still led to very comparable estimates of heritability of V̇o2max. To arrive at a robust estimate for the heritability of V̇o2max in children to young adults, a sample size weighted meta-analysis was performed on all extant twin and sibling studies in this age range. Eight studies, including the current study, were meta-analyzed and resulted in a weighted heritability estimate of 59% (ml/min) and 72% (ml·min(-1)·kg(-1)) for V̇o2max. Taken together, the twin-sibling study and meta-analyses showed that from childhood to early adulthood genetic factors determine more than half of the individual differences in V̇o2max.
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