ArticleHuman brain mapping2016
Alterations in neural systems mediating cognitive flexibility and inhibition in mood disorders.
Article in Human brain mapping, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Fifteen Years Controlling Unwanted Thoughts: A Systematic Review of the Thought Control Ability Questionnaire (TCAQ).Frontiers in psychology · 2019Pooled it
- How to Improve Cognitive Flexibility: Evidence From Noninvasive Neuromodulation Techniques.CNS neuroscience & therapeutics · 2025Review
- Causal structural covariance network identifies progressive gray matter atrophy in adolescents with major depressive disorder.Psychological medicine · 2025Article
- Altered default-mode and frontal-parietal network pattern underlie adaptiveness of emotion regulation flexibility following task-switch training.Social cognitive and affective neuroscience · 2024Article
- Brain-based mechanisms of late-life depression: Implications for novel interventions.Seminars in cell & developmental biology · 2021Review
- Brain functional connectivity dynamics at rest in the aftermath of affective and cognitive challenges.Human brain mapping · 2021Article
- Mood disorders disrupt the functional dynamics, not spatial organization of brain resting state networks.NeuroImage. Clinical · 2021Article
- The role of perceived thought control ability in the psychological functioning of Black American mothers.The American journal of orthopsychiatry · 2021Article
- Cognitive Control Network Homogeneity and Executive Functions in Late-Life Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Posttraumatic Stress Disorder is associated with altered reward mechanisms during the anticipation and the outcome of monetary incentive cues.NeuroImage. Clinical · 2020Article
- Delayed reconfiguration of a non-emotional task set through reactivation of an emotional task set in task switching: an ageing study.Cognition & emotion · 2019Article
- Rumination related activity in brain networks mediating attentional switching in euthymic bipolar patients.International journal of bipolar disorders · 2019Article
- Article
- Contextual and Developmental Differences in the Neural Architecture of Cognitive Control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A closer look at the relationship between the default network, mind wandering, negative mood, and depression.Cognitive, affective & behavioral neuroscience · 2017Article
- Executive Control in Depressive Rumination: Backward Inhibition and Non-inhibitory Switching Performance in a Modified Mixed Antisaccade Task.Frontiers in psychology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impairment in mental flexibility may be a key component contributing to cardinal cognitive symptoms among mood disorders patients, particularly thought control disorders. Impaired ability to switch from one thought to another might reflect difficulties in either generating new mental states, inhibiting previous states, or both. However, the neural underpinnings of impaired cognitive flexibility in mood disorders remain largely unresolved. We compared a group of mood disorders patients (n = 29) and a group of matched healthy subjects (n = 32) on a novel task-switching paradigm involving happy and sad faces, that allowed us to separate generation of a new mental set (Switch Cost) and inhibition of the previous set during switching (Inhibition Cost), using fMRI. Behavioral data showed a larger Switch Cost in patients relative to controls, but the average Inhibition Cost did not differ between groups. At the neural level, a main effect of group was found with stronger activation of the subgenual cingulate cortex in patients. The larger Switch Cost in patients was reflected by a stronger recruitment of brain regions involved in attention and executive control, including the left intraparietal sulcus, precuneus, left inferior fontal gyrus, and right anterior cingulate. Critically, activity in the subgenual cingulate cortex was not downregulated by inhibition in patients relative to controls. In conclusion, mood disorder patients have exaggerated Switch Cost relative to controls, and this deficit in cognitive flexibility is associated with increased activation of the fronto-parietal attention networks, combined with impaired modulation of the subgenual cingulate cortex when inhibition of previous mental states is needed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.