Evidence map›Paper›PMID 26786754›Full record

ArticleRNA biology2017

Selective inhibitors of trypanosomal uridylyl transferase RET1 establish druggability of RNA post-transcriptional modifications.

Amy Cording, Michael Gormally, Peter J Bond, Mark Carrington, Shankar Balasubramanian, Eric A Miska, Beth Thomas

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Amy Cordinga The Gurdon Institute, University of Cambridge , Cambridge , UK.
Michael Gormallyb Department of Chemistry , University of Cambridge , Cambridge , UK.
Peter J Bonde Bioinformatics Institute (A*STAR) , Singapore.
Mark Carringtong Department of Biochemistry , Cambridge , UK.
Shankar Balasubramanianb Department of Chemistry , University of Cambridge , Cambridge , UK.
Eric A Miskaa The Gurdon Institute, University of Cambridge , Cambridge , UK.
Beth Thomasb Department of Chemistry , University of Cambridge , Cambridge , UK.
University of Cambridge · GBNational Center for Advancing Translational Sciences · USNational University of Singapore · SGWellcome/Cancer Research UK Gurdon Institute · GB

Funding

Cancer Research UK 11832Cancer Research UK RG51661
6 · The paper itself

Abstract

Non-coding RNAs are crucial regulators for a vast array of cellular processes and have been implicated in human disease. These biological processes represent a hitherto untapped resource in our fight against disease. In this work we identify small molecule inhibitors of a non-coding RNA uridylylation pathway. The TUTase family of enzymes is important for modulating non-coding RNA pathways in both human cancer and pathogen systems. We demonstrate that this new class of drug target can be accessed with traditional drug discovery techniques. Using the Trypanosoma brucei TUTase, RET1, we identify TUTase inhibitors and lay the groundwork for the use of this new target class as a therapeutic opportunity for the under-served disease area of African Trypanosomiasis. In a broader sense this work demonstrates the therapeutic potential for targeting RNA post-transcriptional modifications with small molecules in human disease.

Indexed as

Drug DiscoveryHumansNucleic Acid Synthesis InhibitorsProtozoan ProteinsRNA EditingRNA NucleotidyltransferasesRNA, UntranslatedTrypanocidal AgentsTrypanosoma brucei bruceiTrypanosomiasis, AfricanUridine TriphosphateNucleic Acid Synthesis InhibitorsProtozoan ProteinsRNA NucleotidyltransferasesRNA, UntranslatedTrypanocidal AgentsUridine TriphosphateUTP-RNA uridylyltransferaseAfrican trypanosomiasisdrug-discoverynon-coding RNApost-transcriptional modificationRET1RNA modificationstrypanosomeTUTaseuridylylation

Identifiers

PMID26786754
PMCPMC5449093
OpenAlexW2267402534

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.