Evidence map›Paper›PMID 26786379›Full record

ArticleAddiction biology2017

Chronic alcohol exposure disrupts CB

Florence P Varodayan, Michal Bajo, Neeraj Soni, George Luu, Samuel G Madamba, Paul Schweitzer, Marisa Roberto

Open access · greenAbstract read
In one paragraph

Article in Addiction biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Alcohol and the brain: from genes to circuits.Trends in neurosciences · 2021
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. CBAddiction biology · 2018
    Article
  14. Review
  15. Article
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Florence P VarodayanCommittee on the Neurobiology of Addictive Disorders, The Scripps Research Institute (TSRI), La Jolla, CA, USA.
Michal BajoCommittee on the Neurobiology of Addictive Disorders, The Scripps Research Institute (TSRI), La Jolla, CA, USA.
Neeraj SoniCommittee on the Neurobiology of Addictive Disorders, The Scripps Research Institute (TSRI), La Jolla, CA, USA.
George LuuCommittee on the Neurobiology of Addictive Disorders, The Scripps Research Institute (TSRI), La Jolla, CA, USA.
Samuel G MadambaCommittee on the Neurobiology of Addictive Disorders, The Scripps Research Institute (TSRI), La Jolla, CA, USA.
Paul SchweitzerCommittee on the Neurobiology of Addictive Disorders, The Scripps Research Institute (TSRI), La Jolla, CA, USA.
Marisa RobertoCommittee on the Neurobiology of Addictive Disorders, The Scripps Research Institute (TSRI), La Jolla, CA, USA.
Scripps Research Institute · USUniversity of Copenhagen · DK

Funding

Viral Vector CoreP60AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2003 to 2026
$46.3M
Electrophysiology of alcohol in extended amygdelaU01AA013498 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI MARISA ROBERTO · 2001 to 2026
$12.6M
SYSTEMIC NEUROPHARMACOLOGYP50AA006420 · NIAAA · SCRIPPS RESEARCH INSTITUTE · PI KOOB, GEORGE F · 1985 to 2002
$5.1M
Regulation of Ethanol Effects on Synaptic TransmissionR01AA015566 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2006 to 2019
$4.6M
Neuroplasticity of the Extended Amygdala CRF circuitry in alcohol dependenceR01AA021491 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2013 to 2024
$3.9M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR37AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2016 to 2025
$3.7M
Gene-environment interaction: the brain CRF system in alcohol preferring msP ratsR01AA017447 · NIAAA · SCRIPPS RESEARCH INSTITUTE, THE · PI ROBERTO, MARISA · 2009 to 2013
$1.8M
NIAAA NIH HHS P50 AA006420NIAAA NIH HHS P60 AA006420NIAAA NIH HHS R01 AA015566NIAAA NIH HHS R01 AA017447NIAAA NIH HHS R01 AA021491NIAAA NIH HHS R37 AA017447NIAAA NIH HHS U01 AA013498
6 · The paper itself

Abstract

The basolateral nucleus of the amygdala (BLA) is critical to the pathophysiology of anxiety-driven alcohol drinking and relapse. The endogenous cannabinoid/type 1 cannabinoid receptor (eCB/CB

Indexed as

AlcoholismAnimalsBasolateral Nuclear ComplexCentral Nervous System DepressantsDisease Models, AnimalEthanolgamma-Aminobutyric AcidMaleRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1Synaptic TransmissionCentral Nervous System DepressantsEthanolgamma-Aminobutyric AcidReceptor, Cannabinoid, CB1Basolateral amygdalaendocannabinoid (eCB)ethanolGABAtype 1 cannabinoid receptor (CB1)whole cell recordings

Identifiers

PMID26786379
PMCPMC4956605
OpenAlexW2416387680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.