Evidence map›Paper›PMID 26786351›Full record

Trial reportInternational journal of obesity (2005)2016

Strong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention.

J Otten, C Mellberg, M Ryberg, S Sandberg, J Kullberg, B Lindahl, C Larsson, J Hauksson, T Olsson

Open access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 7 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 7 syntheses or guidelines pooled it, 60 citations in OpenAlex.

  1. Pooled it
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  5. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
  6. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
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  20. [Research progress of non-alcoholic fatty liver disease in postmenopausal women].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

J OttenDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
C MellbergDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
M RybergDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
S SandbergDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
J KullbergDepartment of Radiology, Uppsala University, Uppsala, Sweden.
B LindahlDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
C LarssonDepartment of Food and Nutrition, and Sport Science, University of Gothenburg, Gothenburg, Sweden.
J HaukssonCenter for Medical Technology and Radiation Physics, Umeå University Hospital, Umeå, Sweden.
T OlssonDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Umeå University · SEUniversity of Gothenburg · SEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesOur objective was to investigate changes in liver fat and insulin sensitivity during a 2-year diet intervention. An ad libitum Paleolithic diet (PD) was compared with a conventional low-fat diet (LFD). SUBJECTS/

methodsSeventy healthy, obese, postmenopausal women were randomized to either a PD or a conventional LFD. Diet intakes were ad libitum. Liver fat was measured with proton magnetic resonance spectroscopy. Insulin sensitivity was evaluated with oral glucose tolerance tests and calculated as homeostasis model assessment-insulin resistance (HOMA-IR)/liver insulin resistance (Liver IR) index for hepatic insulin sensitivity and oral glucose insulin sensitivity (OGIS)/Matsuda for peripheral insulin sensitivity. All measurements were performed at 0, 6 and 24 months. Forty-one women completed the examinations for liver fat and were included.

resultsLiver fat decreased after 6 months by 64% (95% confidence interval: 54-74%) in the PD group and by 43% (27-59%) in the LFD group (P<0.01 for difference between groups). After 24 months, liver fat decreased 50% (25-75%) in the PD group and 49% (27-71%) in the LFD group. Weight reduction between baseline and 6 months was correlated to liver fat improvement in the LFD group (rs=0.66, P<0.01) but not in the PD group (rs=0.07, P=0.75). Hepatic insulin sensitivity improved during the first 6 months in the PD group (P<0.001 for Liver IR index and HOMA-IR), but deteriorated between 6 and 24 months without association with liver fat changes.

conclusionsA PD with ad libitum intake had a significant and persistent effect on liver fat and differed significantly from a conventional LFD at 6 months. This difference may be due to food quality, for example, a higher content of mono- and polyunsaturated fatty acids in the PD. Changes in liver fat did not associate with alterations in insulin sensitivity.

Indexed as

Diet, Fat-RestrictedDiet, PaleolithicInsulin ResistanceBlood GlucoseBlood PressureFemaleGlucose Tolerance TestHumansLipidsLiverMiddle AgedNon-alcoholic Fatty Liver DiseaseObesityPostmenopauseSwedenTime FactorsBlood GlucoseLipids

Identifiers

PMID26786351
OpenAlexW2276275471

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.