ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016
Perceived stress and risk of any osteoporotic fracture.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The Use of Antidepressive Agents and Bone Mineral Density in Women: A Meta-Analysis.International journal of environmental research and public health · 2018Pooled it
- Repeated social defeat causes bone loss from mouse femur.Brain, behavior, & immunity - health · 2026Article
- Increased risk of hip and other major osteoporotic fractures within 18 months of lymphoma diagnosis-a national registry study of 36,864 Swedish lymphoma patients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Association between perceived stress and the risk of continued opioid use after total hip arthroplasty in patients with osteoarthritis: a Danish registry-based study of 1,727 individuals.Acta orthopaedica · 2025Article
- Perceived stress across population segments characterized by differing stressor profiles-A latent class analysis.PloS one · 2025Article
- Comprehensive health assessment of retired martial arts athletes: bone density, dietary intake, physical activity, and wellbeing.Frontiers in aging · 2025Article
- Osteoporosis under psychological stress: mechanisms and therapeutics.Life medicine · 2024Review
- The relative importance of work-related and non-work-related stressors and perceived social support on global perceived stress in a cross-sectional population-based sample.BMC public health · 2021Article
- Article
- Potential mechanisms linking psychological stress to bone health.International journal of medical sciences · 2021Review
- Is there association between stress and periodontitis?Clinical oral investigations · 2020Article
- Post-traumatic stress disorder and incident fractures in the Danish population.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Comparison between locked and unlocked intramedullary nails in intertrochanteric fractures.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2018Article
- Missing data and multiple imputation in clinical epidemiological research.Clinical epidemiology · 2017Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
unlabelledPerceived stress is associated with several adverse health outcomes; however, little is known about the impact of stress on fracture risk. In this population-based cohort study, persons with high perceived stress have an increased 5-year risk of any osteoporotic fracture, in particular hip fracture.
introductionWe conducted a population-based cohort study in Denmark to examine the association between perceived stress and risk of subsequent osteoporotic fracture.
methodsA 2006 population-based health survey in the Central Danish Region (with 1.25 million inhabitants) was used to identify 7943 persons who were 55 years or older on the survey date and completed the Perceived Stress Scale. Individuals were categorized into two groups: high level of stress and low level of stress (including no stress). We obtained information on all osteoporotic fractures through linkage to the Danish National Registry of Patients. We used Cox regression to compute hazard ratios (HRs) with 95 % confidence interval (CI) adjusted for a number of lifestyle factors, socioeconomic data, perceived general health, and prescription history, comparing high- and low-stress persons.
resultsA total of 1799 persons (22.6 %) reported high level of perceived stress, whereas 6144 (77.4 %) reported low level or no stress. The 5-year risk of any osteoporotic fracture was 7.4 and 5.4 % in persons with high and low perceived stress, respectively, corresponding to adjusted HR of 1.37 (CI 1.00-1.89). The adjusted HR for hip fracture within 5 years associated with high perceived stress was 1.68 (CI 1.04-2.72). The associations weakened with increasing follow-up time.
conclusionsPersons with high perceived stress have an increased risk of any osteoporotic fracture, in particular risk of hip fracture within 5 years of stress assessment even after adjusting for differences in lifestyle, comorbidities, osteoporosis presence, medication use, and socioeconomic status at the time of stress level evaluation. The association attenuated after longer follow-up time.
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