Evidence map›Paper›PMID 26785823›Full record

ArticleFEBS letters2016

Membrane interactions and self-association of components of the Ess/Type VII secretion system of Staphylococcus aureus.

Franziska Jäger, Martin Zoltner, Holger Kneuper, William N Hunter, Tracy Palmer

Open access · hybridAbstract readComparative Study
In one paragraph

Article in FEBS letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
  2. Article
  3. The Type VII Secretion System ofAnnual review of microbiology · 2021
    Article
  4. Review
  5. Article
  6. A membrane-depolarizing toxin substrate of theProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Functional analysis of the EsaB component of theMicrobiology (Reading, England) · 2017
    Article
  13. Article
  14. Article
  15. Frontiers in cellular and infection microbiology · 2017
    Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Franziska JägerDivisions of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, UK.
Martin ZoltnerBiological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.
Holger KneuperDivisions of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, UK.
William N HunterBiological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.
Tracy PalmerDivisions of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee, UK.
University of Dundee · GB

Funding

Biotechnology and Biological Sciences Research Council BB/J01446X/1Medical Research Council MR/M011224/1
6 · The paper itself

Abstract

The Ess/Type VII protein secretion system, essential for virulence of pathogenic Staphylococcus aureus, is dependent upon the four core membrane proteins EssA, EssB, EssC and EsaA. Here, we use crosslinking and blue native PAGE analysis to show that the EssB, EssC and EsaA proteins individually form homomeric complexes. Surprisingly, these components appear unable to interact with each other, or with the EssA protein. We further show that two high molecular weight multimers of EssC detected in whole cells are not dependent upon the presence of EsxA, EsxB or any other Ess component for their assembly.

Indexed as

Models, BiologicalBacterial ProteinsCross-Linking ReagentsDetergentsDigitoninDimerizationFormaldehydeGene DeletionGlucosidesMolecular WeightNative Polyacrylamide Gel ElectrophoresisOctoxynolOpen Reading FramesPhosphorylcholinePolymersRecombinant Fusion ProteinsBacterial ProteinsCross-Linking ReagentsDetergentsDigitonindisuccinimidyl suberatedodecyl maltosidedodecylphosphocholineFormaldehydeGlucosidesOctoxynolparaformPhosphorylcholinePolymersRecombinant Fusion ProteinsRecombinant ProteinsSuccinimidesType VII Secretion Systemsmembrane protein complexprotein secretionStaphylococcusaureusType VII secretion

Identifiers

PMID26785823
PMCPMC4949537
OpenAlexW2261120020

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.