ArticleSchizophrenia research2016
Marijuana use in the immediate 5-year premorbid period is associated with increased risk of onset of schizophrenia and related psychotic disorders.
Article in Schizophrenia research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene × environment moderation and mediation.Psychological medicine · 2023Article
- Substance use Specificities in Women with Psychosis: A Critical Review.Current neuropharmacology · 2023Review
- Variations of cannabis-related adverse mental health and addiction outcomes across adolescence and adulthood: A scoping review.Frontiers in psychiatry · 2022Article
- Computational linguistic analysis applied to a semantic fluency task: A replication among first-episode psychosis patients with and without derailment and tangentiality.Psychiatry research · 2021Article
- Associations Between Childhood and Adolescence Adversity and Risk for Arrest Among Patients With First-Episode Psychosis.Psychiatric services (Washington, D.C.) · 2021Article
- Similarities and Differences in Associations Between Duration of Untreated Psychosis (DUP) and Demographic, Premorbid, and Symptom Severity Measures in Two Samples of First-Episode Psychosis Patients from Mexico and the United States.The Psychiatric quarterly · 2020Article
- The Association Between Cannabis Use and Schizophrenia: Causative or Curative? A Systematic Review.Cureus · 2020Review
- A Retrospective Study of the Clinical Characteristics Associated with Alcohol and Cannabis use in Early Phase Psychosis.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2020Article
- Neighborhood-level predictors of age at onset and duration of untreated psychosis in first-episode psychotic disorders.Schizophrenia research · 2020Article
- Unraveling the Intoxicating and Therapeutic Effects of Cannabis Ingredients on Psychosis and Cognition.Frontiers in psychology · 2020Review
- Does the Fast Track Intervention Prevent Later Psychosis Symptoms?Prevention science : the official journal of the Society for Prevention Research · 2019Article
- Developmental considerations in survival models as applied to substance use research.Addictive behaviors · 2019Article
- Factor structure of the Cannabis Experiences Questionnaire in a first-episode psychosis sample.Early intervention in psychiatry · 2019Article
- Cannabis and mental illness: a review.European archives of psychiatry and clinical neuroscience · 2019Review
- Association of Primary Care Consultation Patterns With Early Signs and Symptoms of Psychosis.JAMA network open · 2018Article
- Demographic and socioenvironmental predictors of premorbid marijuana use among patients with first-episode psychosis.Schizophrenia research · 2018Article
- Therapeutic potential of medicinal marijuana: an educational primer for health care professionals.Drug, healthcare and patient safety · 2018Review
- Investigation of theBrain and behavior · 2017Article
- Adverse Structural and Functional Effects of Marijuana on the Brain: Evidence Reviewed.Pediatric neurology · 2017Review
- What Should We Tell Our Patients About Marijuana (Integrative medicine (Encinitas, Calif.) · 2016Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectivesSeveral studies suggest that adolescent marijuana use predicts earlier age at onset of schizophrenia, which is a crucial prognostic indicator. Yet, many investigations have not adequately established a clear temporal relationship between the use and onset.
methodsWe enrolled 247 first-episode psychosis patients from six psychiatric units and collected data on lifetime marijuana/alcohol/tobacco use, and ages at onset of prodrome and psychosis in 210 of these patients. Cox regression (survival analysis) was employed to quantify hazard ratios (HRs) for effects of diverse premorbid use variables on psychosis onset.
resultsEscalation of premorbid use in the 5years prior to onset was highly predictive of an increased risk for onset (e.g., increasing from no use to daily use, HR=3.6, p<0.0005). Through the analysis of time-specific measures, we determined that daily use approximately doubled the rate of onset (HR=2.2, p<0.0005), even after controlling for simultaneous alcohol/tobacco use. Building on previous studies, we were able to determine that cumulative marijuana exposure was associated with an increased rate of onset of psychosis (p=0.007), independent of gender and family history, and this is possibly the reason for age at initiation of marijuana use also being associated with rate of onset in this cohort.
conclusionsThese data provide evidence of a clear temporal relationship between escalations in use in the five years pre-onset and an increased rate of onset, demonstrate that the strength of the association is similar pre- and post-onset of prodromal symptoms, and determine that early adult use may be just as important as adolescent use in these associations.
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