ArticleThorax1989
The immunological component of the cellular inflammatory infiltrate in bronchiectasis.
Article in Thorax, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 85 citations in OpenAlex.
- Crosstalk between the microbiome and the mucosal immunoglobulin A system in the lung, in health and disease.Frontiers in cellular and infection microbiology · 2026Review
- Inflammatory Phenotypes of Bronchiectasis.Journal of personalized medicine · 2025Review
- The role of T-helper and T regulatory cells in driving neutrophilic and eosinophilic inflammation in bronchiectasis.Frontiers in immunology · 2025Review
- Cough in non-cystic fibrosis bronchiectasis.ERJ open research · 2024Article
- Systemic Inflammatory Biomarkers Define Specific Clusters in Patients with Bronchiectasis: A Large-Cohort Study.Biomedicines · 2022Article
- The Role of Epstein-Barr Virus in Adults With Bronchiectasis: A Prospective Cohort Study.Open forum infectious diseases · 2020Article
- Cellular elements organization in the trachea of mallard (Anas platyrhynchos) with a special reference to its local immunological role.Protoplasma · 2020Article
- The Bronchiectasis in COPD-OSA Overlap Syndrome Patients.International journal of chronic obstructive pulmonary disease · 2020Article
- Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis.BMC pulmonary medicine · 2018Review
- The Role of the Immune Response in the Pathogenesis of Bronchiectasis.BioMed research international · 2018Review
- Detection of helicobacter pylori in bronchoalveolar lavage of patients with chronic obstructive pulmonary disease by real time polymerase chain reaction.Jundishapur journal of microbiology · 2015Article
- Increased Peripheral Blood Pro-Inflammatory/Cytotoxic Lymphocytes in Children with Bronchiectasis.PloS one · 2015Article
- Cell counting in human endobronchial biopsies--disagreement of 2D versus 3D morphometry.PloS one · 2014Article
- Immune mechanisms and the impact of the disrupted lung microbiome in chronic bacterial lung infection and bronchiectasis.Clinical and experimental immunology · 2013Review
- Human leucocyte antigen class II association in idiopathic bronchiectasis, a disease of chronic lung infection, implicates a role for adaptive immunity.Clinical and experimental immunology · 2008Article
- Helicobacter pylori infection and respiratory diseases: a review.World journal of gastroenterology · 2003Review
- Benefits and risks of inhaled corticosteroids in chronic obstructive pulmonary disease.Drug safety · 2002Review
- Article
- Review
- Lung infections. 1. Role of bacteria in the pathogenesis and progression of acute and chronic lung infection.Thorax · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunohistological analysis of bronchial biopsy specimens from nine patients with bronchiectasis and four control subjects was performed with a panel of monoclonal antibodies selected to show lymphocyte and macrophage subsets and signs of cellular activation. The cells taking part in the inflammatory response in the bronchial wall of patients with bronchiectasis were almost exclusively mononuclear cells, most of them T lymphocytes. B lymphocytes were observed in biopsy specimens from only two out of nine patients. CD8+ T cells outnumbered CD4+ cells in all patients in a ratio ranging from 2:1 to 10:1. Most T lymphocytes also strongly expressed CD7 antigen and a proportion of them expressed HLA-DR. Most of the lymphocytic infiltration occurred just beneath the basement membrane of the epithelium, though intraepithelial and submucosal infiltration was also seen. Non-lymphoid mononuclear cells expressing the phenotype of dendritic cells and macrophages were found dispersed throughout the infiltrate, most of them expressing HLA-DR. These observations support the hypothesis that cell mediated immunological reactions contribute to the inflammation associated with bronchiectasis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.