Evidence map›Paper›PMID 26785764›Full record

Trial reportEuropean journal of clinical nutrition2016

A longitudinal study of systemic inflammation and recovery of lean body mass among malnourished HIV-infected adults starting antiretroviral therapy in Tanzania and Zambia.

G PrayGod, M Blevins, S Woodd, A M Rehman, K Jeremiah, H Friis, P Kelly, J Changalucha, D C Heimburger, S Filteau and 1 more

Erratum issued Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03106480 (Diabetes and Associated Complications in HIV Patients), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03106480 unknown statusnot on this map

Diabetes and Associated Complications in HIV Patients

TypeobservationalSponsorNational Institute for Medical Research, TanzaniaRan2016 to 2022Enrolled1,947ConditionsDiabetes Mellitus, HIV/AIDS
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

11 authors at 5 institutions in 5 countries.

G PrayGodMwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.
M BlevinsDepartment of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN, USA.
S WooddFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
A M RehmanFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
K JeremiahMwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.
H FriisDepartment of Nutrition, Exercise, and Sports, University of Copenhagen, Copenhagen, Denmark.
P KellyUniversity Teaching Hospital, Lusaka, Zambia.
J ChangaluchaMwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.
D C HeimburgerVanderbilt Institute for Global Health, Nashville, TN, USA.
S FilteauFaculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
J R KoetheVanderbilt Institute for Global Health, Nashville, TN, USA.
London School of Hygiene & Tropical Medicine · GBNational Institute for Medical Research · TZVanderbilt University · USQueen Mary University of London · GBUniversity of Copenhagen · DK

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Medical Research Council MR/K012126/1NCATS NIH HHS UL1TR000445
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe effects of inflammation on nutritional rehabilitation after starting antiretroviral therapy (ART) are not well understood. We assessed the relationship between inflammation and body composition among patients enrolled in the Nutritional Support for African Adults Starting Antiretroviral therapy (NUSTART) trial in Tanzania and Zambia from 2011 to 2013. SUBJECTS/

methodsHIV-infected, ART-eligible adults with body mass index (BMI) of <18.5 kg/m(2) enrolled in the NUSTART trial were eligible for this study. Anthropometric and body composition data were collected at recruitment and 6 and 12 weeks post ART and C-reactive protein (CRP) was measured at recruitment and 6 weeks. The relationships between CRP and body composition were assessed using multiple regression.

resultsOf the 1815 trial participants, 838 (46%) had baseline and 6-week CRP measurements. Median age was 36 years, 55% were females and median CD4 count was 135 cells/μl. A one-log reduction in CRP at 6 weeks was associated with increased mid-upper arm circumference (0.45 cm; 95% CI: 0.30, 0.61), calf circumference (0.38 cm; 0.23, 0.54), waist circumference (0.98 cm; 0.59, 1.37), BMI (0.37 kg/m(2); 0.24, 0.50) and fat-free mass (0.58 kg; 0.26, 0.91), but not with fat mass (0.09 kg; -0.17, 0.34). Fat-free mass gains persisted at 12 weeks and were more closely associated with 6-week CRP values than with baseline values.

conclusionsReduction in CRP shortly after ART initiation was associated with higher fat-free mass gains. Further studies are warranted to determine whether interventions to reduce systemic inflammation will enhance gains in fat-free mass.

Indexed as

Body CompositionAdultAnti-HIV AgentsBody Mass IndexCD4 Lymphocyte CountC-Reactive ProteinDouble-Blind MethodFemaleHIV InfectionsHumansInflammationLongitudinal StudiesMaleMalnutritionNutritional SupportProspective StudiesAnti-HIV AgentsC-Reactive Protein

Identifiers

PMID26785764
OpenAlexW2330660967

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.