Evidence map›Paper›PMID 26785701›Full record

SynthesisScientific reports2016

Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.

Wanqing Wen, Norihiro Kato, Joo-Yeon Hwang, Xingyi Guo, Yasuharu Tabara, Huaixing Li, Rajkumar Dorajoo, Xiaobo Yang, Fuu-Jen Tsai, Shengxu Li and 66 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

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  9. Maternal obesity and ancestry distance in influencing birth outcomes.International journal of obesity (2005) · 2025
    Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

76 authors at 20 institutions in 8 countries.

Wanqing WenDepartment of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Norihiro KatoDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 1628655, Japan.
Joo-Yeon HwangCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Xingyi GuoDepartment of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Yasuharu TabaraCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Huaixing LiKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Rajkumar DorajooGenome Institute of Singapore, Agency for Science, Technology and Research, Singapore.
Xiaobo YangCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.
Fuu-Jen TsaiSchool of Chinese Medicine, China Medical University, Taichung, Taiwan.
Shengxu LiDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Ying WuDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Tangchun WuKey Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Soriul KimInstitute for Health Promotion, Yonsei University, Seodaemun-Gu, Seoul 120-749, Korea.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Jun LiangDepartment of Endocrinology, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu, China.
Dmitry ShunginDepartment of Clinical Sciences, Genetic &Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hospital, Malmö 205 02, Sweden.
Linda S AdairDepartment of Medical Chemistry, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Koichi AkiyamaState Key Laboratory of Molecular Oncology, Cancer Institute &Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Matthew AllisonDivision of Preventive Medicine, Department of Family and Preventive Medicine, University of California, San Diego School of Medicine, San Diego, California, USA.
Qiuyin CaiDepartment of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Li-Ching ChangNational Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chien-Hsiun ChenNational Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yuan-Tsong ChenNational Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Yoon Shin ChoCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Bo Youl ChoiDepartment of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Korea.
Yutang GaoShanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Min Jin GoCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Dongfeng GuDivision of Population Genetics, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Bok-Ghee HanCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Meian HeKey Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
James E HixsonHuman Genetics Center, University of Texas School of Public Health, Houston, Texas, USA.
Yanling HuCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.
Tao HuangDepartment of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Masato IsonoDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 1628655, Japan.
Keum Ji JungInstitute for Health Promotion, Yonsei University, Seodaemun-Gu, Seoul 120-749, Korea.
Daehee KangDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
Young Jin KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Yoshikuni KitaDepartment of Nursing, Tsuruga University of Nursing, Tsuruga, Japan.
Juyoung LeeCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Nanette R LeeOffice of Population Studies Foundation Inc., University of San Carlos, Talamban, Cebu City, Philippines.
Jeannette LeeSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Yiqin WangKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Jian-Jun LiuSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Jirong LongDepartment of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Sanghoon MoonCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Yasuyuki NakamuraDepartment of Health Science, Shiga University of Medical Science, Shiga, Japan.
Masahiro NakatochiBioinformatics Section, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Showa-ku, Nagoya 466-8560, Japan.
Keizo OhnakaDepartment of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
Dabeeru RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
Jiajun ShiDepartment of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Jae Woong SullEulji University, Seongnam City, Gyeonggi-do, Korea.
Aihua TanCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.
Hirotsugu UeshimaDepartment of Health Science, Shiga University of Medical Science, Shiga, Japan.
Chen WuState Key Laboratory of Molecular Oncology, Cancer Institute &Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yong-Bing XiangShanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Ken YamamotoDepartment of Medical Chemistry, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Jie YaoInstitute for Translational Genomics and Population Sciences, Department of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Xingwang YeKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Mitsuhiro YokotaDepartment of Genome Science, Aichi-Gakuin University, School of Dentistry, Chikusa-ku, Nagoya, 464-8651, Japan.
Xiaomin ZhangKey Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Yan ZhengDepartment of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Lu QiDepartment of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Department of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Sun Ha JeeInstitute for Health Promotion, Yonsei University, Seodaemun-Gu, Seoul 120-749, Korea.
Dongxin LinState Key Laboratory of Molecular Oncology, Cancer Institute &Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Karen L MohlkeDepartment of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
Zengnan MoCenter for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.
Jer-Yuarn WuNational Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
E Shyong TaiDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Xu LinKey Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Tetsuro MikiCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Bong-Jo KimCenter for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
Fumihiko TakeuchiDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 1628655, Japan.
Wei ZhengDepartment of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Xiao-Ou ShuDepartment of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
Korea National Institute of Health · KRVanderbilt University · USChinese Academy of Medical Sciences & Peking Union Medical College · CNInstitute of Biomedical Sciences, Academia Sinica · TWGuangxi Medical University · CNHarvard University · USHuazhong University of Science and Technology · CNNational Center for Global Health and Medicine · JPShanghai Institutes for Biological Sciences · CNYonsei University · KRKurume University Medical Center · JPNational University of Singapore · SGShanghai Cancer Institute · CNShiga University of Medical Science · JPTulane University · USUCLA Medical Center · USUniversity of North Carolina at Chapel Hill · USAichi Gakuin University · JPAsia University · TWChinese Academy of Sciences · CN

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6M
Research Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6M
Genetic Epidemiology of Blood Pressure InterventionU01HL072507 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2002 to 2008
$7.6M
Shanghai Womens Health StudyUM1CA182910 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2014 to 2018
$5.9M
Shanghai Men's Health StudyUM1CA173640 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHU, XIAO-OU · 2013 to 2017
$4.9M
Shanghai Breast Cancer StudyR01CA064277 · NCI · VANDERBILT UNIVERSITY · PI SHU, XIAO-OU · 1996 to 2012
$4.8M
Cancer Risk Reduction and Diet: A Cohort Study of WomenR37CA070867 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZHENG, WEI · 2009 to 2013
$4.7M
MOLECULAR EPIDEMIOLOGIC STUDY OF BREAST CANCERR01CA090899 · NCI · VANDERBILT UNIVERSITY · PI ZHENG, WEI · 2000 to 2009
$3.5M
FIC NIH HHS R01 TW005596FIC NIH HHS R01 TW008288FIC NIH HHS TW008288FIC NIH HHS TW05596NCATS NIH HHS UL1 TR000124NCI NIH HHS R01 CA064277NCI NIH HHS R01 CA090899NCI NIH HHS R01 CA092585NCI NIH HHS R01 CA118229NCI NIH HHS R01 CA122756NCI NIH HHS R01 CA148667NCI NIH HHS R37 CA070867NCI NIH HHS R37 CA70867NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182910NCRR NIH HHS 1 UL1 RR024975NCRR NIH HHS P20 RR020649NCRR NIH HHS RR20649NCRR NIH HHS UL1 RR024975NHLBI NIH HHS HL085144NHLBI NIH HHS R01 HL085144NHLBI NIH HHS R01 HL087263NHLBI NIH HHS R01HL087263NHLBI NIH HHS R01 HL090682NHLBI NIH HHS R01HL090682NHLBI NIH HHS U01 HL072507NHLBI NIH HHS U01HL072507NICHD NIH HHS P2C HD050924NIDDK NIH HHS DK078150NIDDK NIH HHS DK56350NIDDK NIH HHS P30 DK056350NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK078150NIEHS NIH HHS ES10126NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3 , CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.

Indexed as

Genome-Wide Association StudyQuantitative Trait, HeritableQuantitative Trait LociWaist CircumferenceWaist-Hip RatioAsiaAsian PeopleFemaleGenetic Predisposition to DiseaseHumansMaleObesityPolymorphism, Single NucleotideSex Factors

Identifiers

PMID26785701
PMCPMC4726286
OpenAlexW2269695812

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.