Evidence map›Paper›PMID 26785644›Full record

ArticleJournal of neurovirology2016

Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients.

Hayley Goullee, Antonia L Wadley, Catherine L Cherry, Richard J N Allcock, Michael Black, Peter R Kamerman, Patricia Price

Open access · greenAbstract read
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In one paragraph

Article in Journal of neurovirology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  7. HIV-related Neuropathy: Pathophysiology, Treatment and Challenges.Journal of neurology and experimental neuroscience · 2021
    Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Hayley GoulleeSchool of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.
Antonia L WadleyBrain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa.
Catherine L CherryBrain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa.
Richard J N AllcockSchool of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.
Michael BlackCentre for Comparative Genomics, Murdoch University, Perth, Australia.
Peter R KamermanBrain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa.
Patricia PriceBrain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, South Africa. patricia.price@curtin.edu.au.ORCID 0000-0003-3078-4451
University of the Witwatersrand · ZAThe University of Western Australia · AUBurnet Institute · AUMurdoch University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV-associated sensory neuropathy (HIV-SN) is the most common neurological condition associated with HIV. HIV-SN has characteristics of an inflammatory pathology caused by the virus itself and/or by antiretroviral treatment (ART). Here, we assess the impact of single-nucleotide polymorphisms (SNPs) in a cluster of three genes that affect inflammation and neuronal repair: P2X7R, P2X4R and CAMKK2. HIV-SN status was assessed using the Brief Peripheral Neuropathy Screening tool, with SN defined by bilateral symptoms and signs. Forty-five SNPs in P2X7R, P2X4R and CAMKK2 were genotyped using TaqMan fluorescent probes, in DNA samples from 153 HIV(+) black Southern African patients exposed to stavudine. Haplotypes were derived using the fastPHASE algorithm, and SNP genotypes and haplotypes associated with HIV-SN were identified. Optimal logistic regression models included demographics (age and height), with SNPs (model p < 0.0001; R (2) = 0.19) or haplotypes (model p < 0.0001; R (2) = 0.18, n = 137 excluding patients carrying CAMKK2 haplotypes perfectly associated with SN). Overall, CAMKK2 exhibited the strongest associations with HIV-SN, with two SNPs and six haplotypes predicting SN status in black Southern Africans. This gene warrants further study.

Indexed as

HaplotypesPolymorphism, Single NucleotideAdultAnti-HIV AgentsBlack PeopleCalcium-Calmodulin-Dependent Protein Kinase KinaseCohort StudiesDisease ProgressionFemaleGene ExpressionHIV InfectionsHumansLogistic ModelsMaleMiddle AgedPolyneuropathiesAnti-HIV AgentsCalcium-Calmodulin-Dependent Protein Kinase KinaseCAMKK2 protein, humanP2RX7 protein, humanReceptors, Purinergic P2X4Receptors, Purinergic P2X7StavudineCAMKK2HIVP2X4RP2X7RSensory neuropathy

Identifiers

PMID26785644
OpenAlexW2299116123

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.