Evidence map›Paper›PMID 26785476›Full record

ReviewScience (New York, N.Y.)2015

Healthy aging: The ultimate preventative medicine.

Matt Kaeberlein, Peter S Rabinovitch, George M Martin

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Science (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 6 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 6 syntheses or guidelines pooled it, 318 citations in OpenAlex.

  1. Pooled it
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  10. An epigenetic speedometer to measure Pace of Aging: FraminghamPACE.medRxiv : the preprint server for health sciences · 2026
    Article
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130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Matt KaeberleinDepartment of Pathology, University of Washington, Seattle, WA 98195, USA. kaeber@uw.edu.
Peter S RabinovitchDepartment of Pathology, University of Washington, Seattle, WA 98195, USA.
George M MartinDepartment of Pathology, University of Washington, Seattle, WA 98195, USA. Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
University of Washington · USUniversity of California, Los Angeles · US

Funding

SPECIFICITY OF OXYGEN DNA DAMAGE AND MUTAGENESISP01AG001751 · NIA · UNIVERSITY OF WASHINGTON · PI RABINOVITCH, PETER S · 1985 to 2021
$29.6M
University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Su-In Lee · 1995 to 2026
$27.1M
International Registry of Werner SyndromeR24AG042328 · NIA · UNIVERSITY OF WASHINGTON · PI MARTIN, GEORGE M., OSHIMA, JUNKO · 2012 to 2015
$743k
NIA NIH HHS P01 AG001751NIA NIH HHS P30 AG013280NIA NIH HHS P30AG013280NIA NIH HHS R24 AG042328
6 · The paper itself

Abstract

Age is the greatest risk factor for nearly every major cause of mortality in developed nations. Despite this, most biomedical research focuses on individual disease processes without much consideration for the relationships between aging and disease. Recent discoveries in the field of geroscience, which aims to explain biological mechanisms of aging, have provided insights into molecular processes that underlie biological aging and, perhaps more importantly, potential interventions to delay aging and promote healthy longevity. Here we describe some of these advances, along with efforts to move geroscience from the bench to the clinic. We also propose that greater emphasis should be placed on research into basic aging processes, because interventions that slow aging will have a greater effect on quality of life compared with disease-specific approaches.

Indexed as

AgingHealthAnimalsDietExerciseGeriatricsHumansMortalityPreventive MedicineRisk FactorsTOR Serine-Threonine KinasesTranslational Research, BiomedicalTOR Serine-Threonine Kinases

Identifiers

PMID26785476
PMCPMC4793924
OpenAlexW2262829592

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.