Evidence map›Paper›PMID 26785430›Full record

ArticleAnesthesiology2016

Cognitive Functioning after Surgery in Middle-aged and Elderly Danish Twins.

Unni Dokkedal, Tom G Hansen, Lars S Rasmussen, Jonas Mengel-From, Kaare Christensen

Open access · greenAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Anesthesiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.

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  20. The Danish Twin Registry: An Updated Overview.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Unni DokkedalFrom the Unit of Epidemiology, Biostatistics, and Biodemography, and the Danish Twin Registry, and the Danish Aging Research Center, Department of Public Health, University of Southern Denmark, Odense, Denmark (U.D., J.M.-F., K.C.); Departments of Anaesthesiology and Intensive Care Medicine (T.G.H.), Clinical Biochemistry and Pharmacology (K.C.), and Clinical Genetics (J.M.-F., K.C.), Odense University Hospital, Odense, Denmark; and Department of Anaesthesia, Centre of Head and Orthopaedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark (L.S.R.).
Tom G Hansen
Lars S Rasmussen
Jonas Mengel-From
Kaare Christensen
Odense University Hospital · DKRegion of Southern Denmark · DKRigshospitalet · DKUniversity of Southern Denmark · DK

Funding

TRAJECTORIES OF MORTALITY IN CAENORHABDITIS ELEGANSP01AG008761 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ROACH, DEBORAH A · 1990 to 2008
$17.5M
NIA NIH HHS P01 AG008761NIA NIH HHS P01 AG08761
6 · The paper itself

Abstract

backgroundPostoperative cognitive dysfunction is common, but it remains unclear whether there are long-term adverse cognitive effects of surgery combined with anesthesia. The authors examined the association between exposure to surgery and level of cognitive functioning in a sample of 8,503 middle-aged and elderly twins.

methodsResults from five cognitive tests were compared in twins exposed to surgery, classified as major, minor, hip and knee replacement, or other, with those of a reference group without surgery using linear regression adjusted for sex and age. Genetic and shared environmental confounding was addressed in intrapair analyses of 87 monozygotic and 124 dizygotic same-sexed twin pairs in whom one had a history of major surgery and the other did not.

resultsStatistically significantly lower composite cognitive score was found in twins with at least one major surgery compared with the reference group (mean difference, -0.27; 95% CI, -0.48 to -0.06), corresponding to one tenth of an SD, that is, a negligible effect size. In the intrapair analysis, the surgery-exposed co-twin had the lower cognitive score in 49% (95% CI, 42 to 56%) of the pairs. None of the other groups differed from the reference group except the knee and hip replacement group that tended to have higher cognitive scores (mean difference, 0.35; 95% CI, -0.18 to 0.87).

conclusionsA history of major surgery was associated with a negligibly lower level of cognitive functioning. The supplementary analyses suggest that preoperative cognitive functioning and underlying diseases were more important for cognitive functioning in mid- and late life than surgery and anesthesia.

Indexed as

AgedCognition DisordersDenmarkFemaleGeriatric AssessmentHumansLongitudinal StudiesMalePostoperative Complications

Identifiers

PMID26785430
PMCPMC4719156
OpenAlexW2265967189

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.