ReviewPain2016
Placebo, nocebo, and neuropathic pain.
Review in Pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Placebo and nocebo effects and mechanisms associated with pharmacological interventions: an umbrella review.BMJ open · 2023Pooled it
- Systematic Review and Meta-Analysis of the Placebo Effect and its Correlates in Obsessive Compulsive Disorder.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2023Pooled it
- Placebo response varies between different types of sham acupuncture: A randomized double-blind trial in neck pain patients.European journal of pain (London, England) · 2022Trial
- The Effect of a Pilot Dietary Intervention on Pain Outcomes in Patients Attending a Tertiary Pain Service.Nutrients · 2019Trial
- Efficacy of photobiomodulation therapy in managing iatrogenic trigeminal nerve injury: A retrospective case series.Lasers in medical science · 2025Article
- Predicting Treatment Responses in Patients With Osteoarthritis: Results From Two Phase III Tanezumab Randomized Clinical Trials.Clinical pharmacology and therapeutics · 2023Article
- Is There Clinical Improvement Associated With Intradiscal Therapies? A Comparison Across Randomized Controlled Studies.Global spine journal · 2022Article
- Pain Reduction after Short Exposure to Virtual Reality Environments in People with Spinal Cord Injury.International journal of environmental research and public health · 2021Article
- Placebo effect in the management of chronic pain.BJA education · 2020Review
- Efficacy and tolerability of nortriptyline in the management of neuropathic corneal pain.The ocular surface · 2020Article
- Results of Mirogabalin Treatment for Diabetic Peripheral Neuropathic Pain in Asian Subjects: A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Study.Pain and therapy · 2020Article
- The role of hedonics in the Human Affectome.Neuroscience and biobehavioral reviews · 2019Review
- Clinical relevance of contextual factors as triggers of placebo and nocebo effects in musculoskeletal pain.BMC musculoskeletal disorders · 2018Review
- The analgesic effect of intravenous methylprednisolone on acute neuropathic pain with allodynia due to central cord syndrome: a retrospective study.Journal of pain research · 2018Article
- What Is the Role of the Placebo Effect for Pain Relief in Neurorehabilitation? Clinical Implications From the Italian Consensus Conference on Pain in Neurorehabilitation.Frontiers in neurology · 2018Review
- Psychological Factors Associated with Phantom Limb Pain: A Review of Recent Findings.Pain research & management · 2018Review
- Neuropathic pain.Nature reviews. Disease primers · 2017Review
- Inside the Scrambler Therapy, a Noninvasive Treatment of Chronic Neuropathic and Cancer Pain: From the Gate Control Theory to the Active Principle of Information.Integrative cancer therapiesReview
- In search of a rodent model of placebo analgesia in chronic orofacial neuropathic pain.Neurobiology of pain (Cambridge, Mass.)Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Over the last decade, the apparent increase in placebo responses in randomized controlled trials (RCTs) of neuropathic pain have complicated and potentially limited development and availability of new effective pain medication. Placebo analgesia and nocebo hyperalgesia effects are well described in nociceptive and idiopathic pain conditions, but less is known about the magnitude and mechanisms of placebo and nocebo effects in neuropathic pain. In neuropathic pain, placebo treatments have primarily been used as control conditions for active agents under investigation in RCTs and these placebo responses are typically not controlled for the natural history of pain and other confounding factors. Recently, mechanistic studies that control for the natural history of pain have investigated placebo and nocebo effects in neuropathic pain in their own right. Large placebo analgesia but no nocebo hyperalgesic effects have been found, and the underlying mechanisms are beginning to be elucidated. Here we review placebo and nocebo effects and the underlying mechanisms in neuropathic pain and compare them with those of nociceptive and idiopathic pain. This allows for a novel discussion on how knowledge of psychological, neurobiological, and genetic factors underlying well-controlled placebo effects may help improve the information that can be obtained from and potentially restore the utility of RCTs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.