ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2016
Association between duration of untreated bipolar disorder and clinical outcome: data from a Brazilian sample.
Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of the Interval between the Onset and Management of Bipolar Disorder.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Pooled it
- Personalized use of ketamine and esketamine for treatment-resistant depression.Translational psychiatry · 2024Review
- Correlates of long duration of untreated illness (DUI) in patients with bipolar disorder: results of an observational study.Annals of general psychiatry · 2023Article
- Factors associated with onset-age in major affective disorders.Acta psychiatrica Scandinavica · 2022Article
- The mood disorder spectrum vs. schizophrenia decision tree: EDIPHAS research into the childhood and adolescence of 205 patients.BMC psychiatry · 2022Article
- Can we better understand severe mental illness through the lens of Syndemics?Frontiers in psychiatry · 2022Article
- Safety of 80 antidepressants, antipsychotics, anti-attention-deficit/hyperactivity medications and mood stabilizers in children and adolescents with psychiatric disorders: a large scale systematic meta-review of 78 adverse effects.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020Article
- Clinical presentation and need for treatment of a cohort of subjects accessing to a mental illness prevention service.Research in psychotherapy (Milano) · 2020Article
- Longitudinal course and risk factors associated with psychosis in bipolar youths.Bipolar disorders · 2020Article
- A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia.Progress in neuro-psychopharmacology & biological psychiatry · 2019Review
- Duration of untreated bipolar disorder: a multicenter study.Scientific reports · 2017Article
- Pathways to Care for Patients with Bipolar-I Disorder: An Exploratory Study from a Tertiary Care Centre of North India.Indian journal of psychological medicineArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBipolar disorder (BD) is often left untreated for long periods, and this delay in treatment correlates with unfavorable prognosis. The present study sought to assess the magnitude of duration of untreated bipolar disorder (DUB) in Brazil. We hypothesized that DUB would be longer in Brazil than in developed countries, and would be associated with poor clinical outcomes.
methodsOne hundred and fifty-two psychiatric outpatients were evaluated for BD diagnosis, demographics, DUB, and clinical outcomes.
resultsThe mean age and mean DUB were, respectively, 38.9±10.8 and 10.4±9.8 years. An extended DUB was associated with early onset of BD (p < 0.001), depression as first mood episode (p = 0.04), and presence of BD in a first-degree relative (p = 0.012). Additionally, a longer DUB was associated with poorer clinical outcomes, such as elevated rates of rapid cycling (p = 0.004) and anxiety disorders (p = 0.016), as well as lower levels of current full remission (p = 0.021).
conclusionAs DUB may be a modifiable variable, better medical education regarding mental health, more structured medical services, and population-wide psychoeducation might reduce the time between onset and proper management of BD, thus improving outcome.
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