Evidence map›Paper›PMID 26785053›Full record

ArticlePloS one2016

Change of Th17 Lymphocytes and Treg/Th17 in Typical and Atypical Optic Neuritis.

Hengri Cong, Hanqiu Jiang, Jingting Peng, Shilei Cui, Lijuan Liu, Jiawei Wang, Xiaojun Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Exploring the Ocular Surface Microbiome and Tear Proteome in Glaucoma.International journal of molecular sciences · 2024
    Article
  2. Review
  3. Review
  4. Atypical optic neuritis: An overview.Indian journal of ophthalmology · 2021
    Review
  5. Serum levels of IL-6 and IL-17 in multiple sclerosis, neuromyelitis optica patients and healthy subjects.International journal of physiology, pathophysiology and pharmacology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hengri CongDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Hanqiu JiangDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Jingting PengDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Shilei CuiDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Lijuan LiuEye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Jiawei WangDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Xiaojun ZhangDepartment of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Beijing Tongren Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTypical and atypical optic neuritis (ON) are two clinical types of autoimmune inflammatory diseases of the optic nerve that causes acute vision loss, and are difficult to distinguish in their early stages. The disturbance in the balance of Th17 and Treg lymphocytes is thought to play an essential role in these autoimmune inflammatory diseases.

objectivesTo detect the clinical relevance of Th17 and Treg in peripheral blood and the ratio of Treg/Th17 in patients with typical and atypical ON. To determine whether analysis of Th17 and Treg lymphocytes will provides insights into the different disease phenotypes of typical and atypical ON.

methodsWe studied a consecutive series of patients aged 14-70 years who presented to our neurological department with typical ON (n = 30) or atypical ON (n = 33) within 4 weeks of their acute attacks. Routine clinical tests and ophthalmological examination were performed in all patients. Blood samples were collected from untreated patients and from gender- and age-matched healthy controls (n = 30). The proportion of peripheral blood Th17 cells and Treg cells was determined by flow cytometry.

resultsPatients with atypical ON had a higher proportion of Th17 cells than patients with typical ON (3.61 ± 1.56 vs 2.55 ± 1.74, P<0.01) or controls (1.45 ± 0.86, P<0.01). The proportion of Th17 cells in patients with typical ON was also markedly higher than in controls (P<0.01). The mean percentage of Treg cells in atypical ON (6.31 ± 2.11) and typical ON (6.80 ± 2.00) were significantly lower when compared to controls (8.29 ± 2.32, both P<0.01). No significant difference in Treg frequency was observed between typical ON and atypical ON (p>0.05).

conclusionsThe frequency of Th17 cells is higher in atypical ON than typical ON, and patients with atypical ON have a greater imbalance of pro-inflammatory and regulatory cells than patients with typical ON when compared with controls. These changes are indicative of distinct pathological mechanisms and may provide useful information to distinguish typical and atypical ON.

Indexed as

AdolescentAdultAgedFemaleHumansMaleMiddle AgedOptic NeuritisTh17 CellsT-Lymphocytes, Regulatory

Identifiers

PMID26785053
PMCPMC4718616
OpenAlexW2472743523

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.