ArticleChemistry (Weinheim an der Bergstrasse, Germany)2016
Design and Synthesis of an Alkynyl Luciferin Analogue for Bioluminescence Imaging.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Exclusive Solvent-Controlled Regioselective Catalytic Synthesis of Potentially Bioactive Imidazolidineiminodithiones: NMR Analysis, Computational Studies and X-ray Crystal Structures.Molecules (Basel, Switzerland) · 2024Article
- Computational Investigation of Substituent Effects on the Fluorescence Wavelengths of Oxyluciferin Analogs.Journal of photochemistry and photobiology. A, Chemistry · 2022Article
- Molecular Design of d-Luciferin-Based Bioluminescence and 1,2-Dioxetane-Based Chemiluminescence Substrates for Altered Output Wavelength and Detecting Various Molecules.Molecules (Basel, Switzerland) · 2021Review
- Seeing (and Using) the Light: Recent Developments in Bioluminescence Technology.Cell chemical biology · 2020Review
- Building Biological Flashlights: Orthogonal Luciferases and Luciferins forAccounts of chemical research · 2019Review
- Chemiluminescence and Bioluminescence Imaging for Biosensing and Therapy:Theranostics · 2019Review
- Lessons Learned from Luminous Luciferins and Latent Luciferases.ACS chemical biology · 2018Review
- Novel caged luciferin derivatives can prolong bioluminescence imagingRSC advances · 2018Article
- Pyridone Luciferins and Mutant Luciferases for Bioluminescence Imaging.Chembiochem : a European journal of chemical biology · 2018Article
- Luciferase Activity of Insect Fatty Acyl-CoA Synthetases with Synthetic Luciferins.ACS chemical biology · 2017Article
- New imaging probes to track cell fate: reporter genes in stem cell research.Cellular and molecular life sciences : CMLS · 2017Review
- Economical and scalable synthesis of 6-amino-2-cyanobenzothiazole.Beilstein journal of organic chemistry · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Herein, the synthesis and characterization of an alkyne-modified luciferin is reported. This bioluminescent probe was accessed using C-H activation methodology and was found to be stable in solution and capable of light production with firefly luciferase. The luciferin analogue was also cell permeant and emitted more redshifted light than d-luciferin, the native luciferase substrate. Based on these features, the alkynyl luciferin will be useful for a variety of imaging applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.