ArticlePloS one2016
Safety Assessment of Bacteroides uniformis CECT 7771 Isolated from Stools of Healthy Breast-Fed Infants.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- The effects of next generation probiotics on metabolic dysfunction-associated steatotic liver disease: a parallel, double-blind, randomized, placebo-controlled trial.Journal of translational medicine · 2025Trial
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- Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease.Neurogastroenterology and motility · 2020Trial
- Antibiotic Exposure Through Human Milk Influences the Infant Gut Microbiome.bioRxiv : the preprint server for biology · 2026Article
- Safety and Tolerability of the Gut BacteriumNutrients · 2026Article
- Safety Assessment and Probiotic Potential of a Novel SpeciesNutrients · 2025Article
- Bacteroides uniformis ameliorates pro-inflammatory diet-exacerbated colitis by targeting endoplasmic reticulum stress-mediated ferroptosis.Journal of advanced research · 2025Article
- Recent Advances in Gut Microbiota in Psoriatic Arthritis.Nutrients · 2025Review
- Review
- Bidirectional Interactions between Green Tea (GT) Polyphenols and Human Gut Bacteria.Journal of microbiology and biotechnology · 2023Article
- How Do Prebiotics Affect Human Intestinal Bacteria?-Assessment of Bacterial Growth with Inulin and XOS In Vitro.International journal of molecular sciences · 2023Article
- Positive mood-related gut microbiota in a long-term closed environment: a multiomics study based on the "Lunar Palace 365" experiment.Microbiome · 2023Article
- Effects of Zhishi Daozhi Decoction on the intestinal flora of nonalcoholic fatty liver disease mice induced by a high-fat diet.Frontiers in cellular and infection microbiology · 2022Article
- Amelioration of Hepatic Steatosis in Mice throughNutrients · 2021Article
- Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model.Microbiome · 2021Article
- Effect of Bovine Milk Fat Globule Membrane and Lactoferrin in Infant Formula on Gut Microbiome and Metabolome at 4 Months of Age.Current developments in nutrition · 2021Article
- A Comprehensive Assessment of the Safety ofMicroorganisms · 2021Article
- The influence of blood on the human gut microbiome.BMC microbiology · 2020Article
- Safety Assessment ofNutrients · 2020Article
- Recovery Dynamics of Intestinal Bacterial Communities of CClBioMed research international · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacteroides uniformis CECT 7771 is a potential probiotic strain, originally isolated from the stools of healthy breast-feed infants. The strain showed pre-clinical efficacy in a mouse obesity model. The objective of this study was to evaluate its potential toxicity and translocation ability after acute oral administration to mice. METHODS AND
findingsA safety study was conducted in immunocompetent and immunosuppressed C57BL-6 mice. Both mouse groups (n = 10 per group) were fed orally 2 x 10(9) colony forming units (cfu)/day of B. uniformis CECT 7771 or placebo by gavage for 6 days. Throughout this time, feed and water intake and body weight were monitored. Afterwards, mice were sacrificed and biological samples were collected to analyze blood and urine biochemistry, inflammatory and immune markers; gut mucosal histology and bacterial translocation to peripheral tissues. The results demonstrated that acute ingestion of this Bacteroides strain had no adverse effects on the animals' general health status or food intake, nor did it affect biochemical indicators of liver, kidney and pancreatic function or gut mucosal histology. Findings also demonstrated that administration did not lead to bacterial translocation to blood, liver or mesenteric lymph nodes. B. uniformis CECT 7771 also downregulated gene and protein expression (iNOS and PPAR-γ) and inflammatory cytokines induced by immunosuppression.
conclusionsThe findings indicate that the acute oral consumption of B. uniformis CECT 7771 does not raise safety concerns in mice. Further studies in humans should be conducted.
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