Evidence map›Paper›PMID 26784744›Full record

ArticlePloS one2016

Gray and White Matter Contributions to Cognitive Frontostriatal Deficits in Non-Demented Parkinson's Disease.

Catherine C Price, Jared Tanner, Peter T Nguyen, Nadine A Schwab, Sandra Mitchell, Elizabeth Slonena, Babette Brumback, Michael S Okun, Thomas H Mareci, Dawn Bowers

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
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  7. Corpus callosum integrity loss predicts cognitive impairment in Leukoaraiosis.Annals of clinical and translational neurology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Catherine C PriceDepartment of Clinical and Health Psychology, University of Florida, Gainesville, Florida, United States of America.
Jared TannerDepartment of Clinical and Health Psychology, University of Florida, Gainesville, Florida, United States of America.
Peter T NguyenDepartment of Clinical and Health Psychology, University of Florida, Gainesville, Florida, United States of America.
Nadine A SchwabDepartment of Clinical and Health Psychology, University of Florida, Gainesville, Florida, United States of America.
Sandra MitchellDepartment of Clinical and Health Psychology, University of Florida, Gainesville, Florida, United States of America.
Elizabeth SlonenaDepartment of Clinical and Health Psychology, University of Florida, Gainesville, Florida, United States of America.
Babette BrumbackDepartment of Biostatistics, University of Florida, Gainesville, Florida, United States of America.
Michael S OkunDepartment of Neurology, University of Florida, Gainesville, Florida, United States of America.
Thomas H MareciBiochemistry and Molecular Biology, University of Florida, Gainesville, Florida, United States of America.
Dawn BowersDepartment of Clinical and Health Psychology, University of Florida, Gainesville, Florida, United States of America.
University of Florida · USUniversity of Florida Health · US

Funding

UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
Research Training in Non-Pharmacological Interventions for Cognition in Aging, MCI, and Alzheimer's DiseaseT32AG020499 · NIA · UNIVERSITY OF FLORIDA · PI MARSISKE, MICHAEL, SMITH, GLENN E. · 2003 to 2024
$3.7M
White Matter Connectivity and PD Cognitive PhenotypesR01NS082386 · NINDS · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2013 to 2017
$2.3M
White Matter and Cognition in Parkinson's DiseaseK23NS060660 · NINDS · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2007 to 2011
$619k
NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1TR000064NIA NIH HHS T32 AG020499NINDS NIH HHS K23 NS060660NINDS NIH HHS K23NS60660NINDS NIH HHS R01 NS082386NINDS NIH HHS R01NS082386
6 · The paper itself

Abstract

objectiveThis prospective investigation examined: 1) processing speed and working memory relative to other cognitive domains in non-demented medically managed idiopathic Parkinson's disease, and 2) the predictive role of cortical/subcortical gray thickness/volume and white matter fractional anisotropy on processing speed and working memory.

methodsParticipants completed a neuropsychological protocol, Unified Parkinson's Disease Rating Scale, brain MRI, and fasting blood draw to rule out vascular contributors. Within group a priori anatomical contributors included bilateral frontal thickness, caudate nuclei volume, and prefrontal white matter fractional anisotropy.

resultsIdiopathic Parkinson's disease (n = 40; Hoehn & Yahr stages 1-3) and non-Parkinson's disease 'control' peers (n = 40) matched on demographics, general cognition, comorbidity, and imaging/blood vascular metrics. Cognitively, individuals with Parkinson's disease were significantly more impaired than controls on tests of processing speed, secondary deficits on working memory, with subtle impairments in memory, abstract reasoning, and visuoperceptual/spatial abilities. Anatomically, Parkinson's disease individuals were not statistically different in cortical gray thickness or subcortical gray volumes with the exception of the putamen. Tract Based Spatial Statistics showed reduced prefrontal fractional anisotropy for Parkinson's disease relative to controls. Within Parkinson's disease, prefrontal fractional anisotropy and caudate nucleus volume partially explained processing speed. For controls, only prefrontal white matter was a significant contributor to processing speed. There were no significant anatomical predictors of working memory for either group.

conclusionsCaudate nuclei volume and prefrontal fractional anisotropy, not frontal gray matter thickness, showed unique and combined significance for processing speed in Parkinson's disease. Findings underscore the relevance for examining gray-white matter interactions and also highlight clinical processing speed metrics as potential indicators of early cognitive impairment in PD.

Indexed as

AgedBrain MappingCase-Control StudiesCognition DisordersCorpus StriatumFemaleFrontal LobeGray MatterHumansMagnetic Resonance ImagingMaleNeuropsychological TestsParkinson DiseaseWhite Matter

Identifiers

PMID26784744
PMCPMC4718544
OpenAlexW2435837069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.