ArticlePloS one2016
Camphene, a Plant Derived Monoterpene, Exerts Its Hypolipidemic Action by Affecting SREBP-1 and MTP Expression.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
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- Effects of drying methods on volatile profiles ofFood chemistry: X · 2026Article
- Terpene content in the air of younger and older forests in southeastern Poland: implications for forest therapy.Scientific reports · 2025Article
- A Comparison Analysis of Four Different Drying Treatments on the Volatile Organic Compounds of Gardenia Flowers.Molecules (Basel, Switzerland) · 2024Article
- A Comparison between BulgarianMolecules (Basel, Switzerland) · 2024Article
- Camphene as a Protective Agent in Myocardial Ischemia/Reperfusion Injury.Antioxidants (Basel, Switzerland) · 2024Article
- Review
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- Aroma Profile and Biological Effects ofMolecules (Basel, Switzerland) · 2022Article
- Using Rosemary Essential Oil as a Potential Natural Preservative during Stirred-like Yogurt Making.Foods (Basel, Switzerland) · 2022Article
- Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer's Disease.Molecules (Basel, Switzerland) · 2022Review
- Usage of Natural Volatile Organic Compounds as Biological Modulators of Disease.International journal of molecular sciences · 2021Review
- Recent Molecular Mechanisms and Beneficial Effects of Phytochemicals and Plant-Based Whole Foods in Reducing LDL-C and Preventing Cardiovascular Disease.Antioxidants (Basel, Switzerland) · 2021Review
- Terpenes/Terpenoids inMedical cannabis and cannabinoids · 2020Article
- Antioxidant Properties of Camphene-Based Thiosemicarbazones: Experimental and Theoretical Evaluation.Molecules (Basel, Switzerland) · 2020Article
- Nonhuman primate breath volatile organic compounds associate with developmental programming and cardio-metabolic status.Journal of breath research · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The control of hyperlipidemia plays a central role in cardiovascular disease. Previously, we have shown that camphene, a constituent of mastic gum oil, lowers cholesterol and triglycerides (TG) in the plasma of hyperlipidemic rats without affecting HMG-CoA reductase activity, suggesting that its hypocholesterolemic and hypotriglyceridemic effects are associated with a mechanism of action different than that of statins. In the present study, we examine the mechanism by which camphene exerts its hypolipidemic action. We evaluated the effect of camphene on the de novo synthesis of cholesterol and TG from [14C]-acetate in HepG2 cells, along with the statin mevinolin. Camphene inhibited the biosynthesis of cholesterol in a concentration-dependent manner, and a maximal inhibition of 39% was observed at 100 μM while mevinolin nearly abolished cholesterol biosynthesis. Moreover, treatment with camphene reduced TG by 34% and increased apolipoprotein AI expression. In contrast, mevinolin increased TG by 26% and had a modest effect on apolipoprotein AI expression. To evaluate the mode of action of camphene, we examined its effects on the expression of SREBP-1, which affects TG biosynthesis and SREBP-2, which mostly affects sterol synthesis. Interestingly, camphene increased the nuclear translocation of the mature form of SREBP-1 while mevinolin was found to increase the amount of the mature form of SREBP-2. The effect of camphene is most likely regulated through SREBP-1 by affecting MTP levels in response to a decrease in the intracellular cholesterol. We propose that camphene upregulates SREBP-1 expression and MTP inhibition is likely to be a probable mechanism whereby camphene exerts its hypolipidemic effect.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.