ArticlePsychological medicine2016
Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder.
Article in Psychological medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
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Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Hyperconnectivity between the posterior cingulate and middle frontal and temporal gyrus in depression: Based on functional connectivity meta-analyses.Brain imaging and behavior · 2022Pooled it
- Balancing act: Neural correlates of affect dysregulation in youth depression and substance use - A systematic review of functional neuroimaging studies.Developmental cognitive neuroscience · 2020Pooled it
- Abnormal amygdala resting-state functional connectivity in adults and adolescents with major depressive disorder: A comparative meta-analysis.EBioMedicine · 2018Pooled it
- Trial
- Blunted amygdala activity is associated with depression severity in treatment-resistant depression.Cognitive, affective & behavioral neuroscience · 2017Trial
- Trial
- Reduced amygdala habituation to anticipated social rejection in youth with major depressive disorder.Journal of affective disorders · 2026Article
- Effects of genetic risk for depression and household socioeconomic status on emotional behavior and brain development in early adolescence.Developmental cognitive neuroscience · 2026Article
- Cognitive impairment in idiopathic intracranial hypertension: A conceptual framework and therapeutic implications.Surgical neurology international · 2026Review
- Maltreatment effects on cognitive control functional connectivity across adolescence: Prospective links to young adult mental health.Development and psychopathology · 2025Article
- Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood Disorder.Biological psychiatry global open science · 2025Article
- The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms.Journal of neuroinflammation · 2025Review
- Advances and Challenges in Depression Marker Research.Neuropsychiatric disease and treatment · 2025Review
- Biomarkers of Suicidal Ideation in Depression: Insights From VMHC Analysis and Machine Learning.Neuropsychiatric disease and treatment · 2025Article
- Changes of functional brain network topology associated with nutritional indicator of patients with recurrent major depressive disorder.Frontiers in nutrition · 2025Article
- Relationship between brain structural network integrity and emotional symptoms in youth with perinatally-acquired HIV.Brain, behavior, and immunity · 2024Article
- Weakened effective connectivity between salience network and default mode network during resting state in adolescent depression.Frontiers in psychiatry · 2024Article
- Trait- and state-like co-activation pattern dynamics in current and remitted major depressive disorder.Journal of affective disorders · 2023Article
- Reduced connectivity of the cognitive control neural network at rest in young adults who had their first drink of alcohol prior to age 18.Psychiatry research. Neuroimaging · 2023Article
- Negative association between non-suicidal self-injury in adolescents and default mode network activation during the distraction blocks of a rumination task.Suicide & life-threatening behavior · 2023Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
backgroundRecent meta-analyses of resting-state networks in major depressive disorder (MDD) implicate network disruptions underlying cognitive and affective features of illness. Heterogeneity of findings to date may stem from the relative lack of data parsing clinical features of MDD such as phase of illness and the burden of multiple episodes.
methodResting-state functional magnetic resonance imaging data were collected from 17 active MDD and 34 remitted MDD patients, and 26 healthy controls (HCs) across two sites. Participants were medication-free and further subdivided into those with single v. multiple episodes to examine disease burden. Seed-based connectivity using the posterior cingulate cortex (PCC) seed to probe the default mode network as well as the amygdala and subgenual anterior cingulate cortex (sgACC) seeds to probe the salience network (SN) were conducted.
resultsYoung adults with remitted MDD demonstrated hyperconnectivity of the left PCC to the left inferior frontal gyrus and of the left sgACC to the right ventromedial prefrontal cortex (PFC) and left hippocampus compared with HCs. Episode-independent effects were observed between the left PCC and the right dorsolateral PFC, as well as between the left amygdala and right insula and caudate, whereas the burden of multiple episodes was associated with hypoconnectivity of the left PCC to multiple cognitive control regions as well as hypoconnectivity of the amygdala to large portions of the SN.
conclusionsThis is the first study of a homogeneous sample of unmedicated young adults with a history of adolescent-onset MDD illustrating brain-based episodic features of illness.
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