ArticleThe ISME journal2016
Tuning fresh: radiation through rewiring of central metabolism in streamlined bacteria.
Article in The ISME journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 67 citations in OpenAlex.
- Article
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- Global niche partitioning of purine and pyrimidine cross-feeding among ocean microbes.Science advances · 2025Article
- Polyhydroxybutyrate production by freshwater SAR11 (LD12).The ISME journal · 2025Article
- Macroevolutionary Dynamics in Micro-organisms: Generalists Give Rise to Specialists Across Biomes in the Ubiquitous Bacterial Phylum Myxococcota.Molecular biology and evolution · 2024Article
- Gene inversion led to the emergence of brackish archaeal heterotrophs in the aftermath of the Cryogenian Snowball Earth.PNAS nexus · 2024Article
- Adaptive radiations in natural populations of prokaryotes: innovation is key.FEMS microbiology ecology · 2023Article
- High-throughput metabarcoding of SAR11 assemblages from the southwest Atlantic shelf and arid Patagonia: richness and associated rank abundance distributions.Quantitative biology (Beijing, China) · 2023Article
- Large-scale phylogenomics of aquatic bacteria reveal molecular mechanisms for adaptation to salinity.Science advances · 2023Article
- Global patterns and rates of habitat transitions across the eukaryotic tree of life.Nature ecology & evolution · 2022Article
- On the osmotic pressure of cells.QRB discovery · 2022Article
- Characteristics, Biodiversity, and Cultivation Strategy of Low Nucleic Acid Content Bacteria.Frontiers in microbiology · 2022Review
- Auxotrophic interactions: a stabilizing attribute of aquatic microbial communities?FEMS microbiology ecology · 2020Article
- Article
- Colloidal stability of the living cell.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- Article
- Bacterial succession along a sediment porewater gradient at Lake Neusiedl in Austria.Scientific data · 2019Article
- Niche-specific metabolic adaptation in biotrophic and necrotrophic oomycetes is manifested in differential use of nutrients, variation in gene content, and enzyme evolution.PLoS pathogens · 2019Article
- Gene Expansion and Positive Selection as Bacterial Adaptations to Oligotrophic Conditions.mSphere · 2019Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most free-living planktonic cells are streamlined and in spite of their limitations in functional flexibility, their vast populations have radiated into a wide range of aquatic habitats. Here we compared the metabolic potential of subgroups in the Alphaproteobacteria lineage SAR11 adapted to marine and freshwater habitats. Our results suggest that the successful leap from marine to freshwaters in SAR11 was accompanied by a loss of several carbon degradation pathways and a rewiring of the central metabolism. Examples for these are C1 and methylated compounds degradation pathways, the Entner-Doudouroff pathway, the glyoxylate shunt and anapleuretic carbon fixation being absent from the freshwater genomes. Evolutionary reconstructions further suggest that the metabolic modules making up these important freshwater metabolic traits were already present in the gene pool of ancestral marine SAR11 populations. The loss of the glyoxylate shunt had already occurred in the common ancestor of the freshwater subgroup and its closest marine relatives, suggesting that the adaptation to freshwater was a gradual process. Furthermore, our results indicate rapid evolution of TRAP transporters in the freshwater clade involved in the uptake of low molecular weight carboxylic acids. We propose that such gradual tuning of metabolic pathways and transporters toward locally available organic substrates is linked to the formation of subgroups within the SAR11 clade and that this process was critical for the freshwater clade to find and fix an adaptive phenotype.
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