ArticlePloS one2016
Exploration of Human Salivary Microbiomes--Insights into the Novel Characteristics of Microbial Community Structure in Caries and Caries-Free Subjects.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Salivary microbiota profile in adult and children population according to active dentin caries: a metagenomic preliminary analysis.Frontiers in oral health · 2025Article
- Salivary Metabolites Produced by Oral Microbes in Oral Diseases and Oral Squamous Cell Carcinoma: A Review.Metabolites · 2024Review
- Oral microbiota analyses of paediatric Saudi population reveals signatures of dental caries.BMC oral health · 2023Article
- Salivary microbiome differences in prepubertal children with and without adrenal androgen excess.Pediatric research · 2022Article
- Explorative study on Lactobacillus species and their acid-producing capacity and anti-microbial activity in head and neck cancer patients.Clinical and experimental dental research · 2021Article
- Citizen-science based study of the oral microbiome in Cystic fibrosis and matched controls reveals major differences in diversity and abundance of bacterial and fungal species.Journal of oral microbiology · 2021Article
- Machine Learning Study in Caries Markers in Oral Microbiota from Monozygotic Twin Children.Diagnostics (Basel, Switzerland) · 2021Article
- Relationship between dental and periodontal health status and the salivary microbiome: bacterial diversity, co-occurrence networks and predictive models.Scientific reports · 2021Article
- At the Interface of Life and Death: Post-mortem and Other Applications of Vaginal, Skin, and Salivary Microbiome Analysis in Forensics.Frontiers in microbiology · 2021Review
- Metagenomic Analysis RevealsEvidence-based complementary and alternative medicine : eCAM · 2021Article
- The oral microbiome and salivary proteins influence caries in children aged 6 to 8 years.BMC oral health · 2020Article
- The salivary microbiota in health and disease.Journal of oral microbiology · 2020Review
- Comparison of oral microbiome profiles in stimulated and unstimulated saliva, tongue, and mouth-rinsed water.Scientific reports · 2019Article
- Altered gut microbiota and microbial biomarkers associated with chronic kidney disease.MicrobiologyOpen · 2019Article
- Xylitol and sorbitol effects on the microbiome of saliva and plaque.Journal of oral microbiology · 2019Article
- Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer.Technology in cancer research & treatment · 2019Review
- Citizen science charts two major "stomatotypes" in the oral microbiome of adolescents and reveals links with habits and drinking water composition.Microbiome · 2018Article
- Species Level Description of the Human Ileal Bacterial Microbiota.Scientific reports · 2018Article
- Oral Biofilms: Pathogens, Matrix, and Polymicrobial Interactions in Microenvironments.Trends in microbiology · 2018Review
- Saliva and tooth biofilm bacterial microbiota in adolescents in a low caries community.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, high-throughput sequencing has improved the understanding of the microbiological etiology of caries, but the characteristics of the microbial community structure in the human oral cavity with and without caries are not completely clear. To better understand these characteristics, Illumina MiSeq high-throughput sequencing was utilized to analyze 20 salivary samples (10 caries-free and 10 caries) from subjects from the same town in Dongxiang, Gansu, China. A total of 5,113 OTUs (Operational Taxonomic Units, 97% cutoff) were characterized in all of the salivary samples obtained from the 20 subjects. A comparison of the two groups revealed that (i) the predominant phyla were constant between the two groups; (ii) the relative abundance of the genera Veillonella, Bifidobacterium, Selenomonas, Olsenella, Parascardovia, Scardovia, Chryseobacterium, Terrimonas, Burkholderia and Sporobacter was significantly higher in the group with caries (P < 0.05); and (iii) four genera with low relative abundance (< 0.01% on average), including two characteristic genera in caries (Chryseobacterium and Scardovia), significantly influenced the microbial community structure at the genus and OTU levels. Moreover, via co-occurrence and principal component analyses, the co-prevalence of the pathogenic genera was detected in the caries samples, but in the caries-free samples, the function of clustered genera was more random. This result suggests that a synergistic effect may be influencing the assembly of the caries microbial community, whereas competition may play a more dominant role in governing the microbial community in the caries-free group. Our findings regarding the characteristics of the microbial communities of the groups with and without caries might improve the understanding of the microbiological etiology of caries and might improve the prevention and cure of caries in the future.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.