Evidence map›Paper›PMID 26784174›Full record

ArticleInternational journal of molecular sciences2016

Free Radical Scavenging and Cellular Antioxidant Properties of Astaxanthin.

Janina Dose, Seiichi Matsugo, Haruka Yokokawa, Yutaro Koshida, Shigetoshi Okazaki, Ulrike Seidel, Manfred Eggersdorfer, Gerald Rimbach, Tuba Esatbeyoglu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it.

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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Janina DoseInstitute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Straße 6, D-24118 Kiel, Germany. dose@foodsci.uni-kiel.de.
Seiichi MatsugoSchool of Natural System, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. s-matsugoh@se.kanazawa-u.ac.jp.
Haruka YokokawaSchool of Natural System, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. haruside8133@gmail.com.
Yutaro KoshidaSchool of Natural System, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan. koshi04015087@gmail.com.
Shigetoshi OkazakiMedical Photonics Research Center, Hamamatsu University School of Medicine, Handamachi 1-20-1, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan. okazaki@hama-med.ac.jp.
Ulrike SeidelInstitute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Straße 6, D-24118 Kiel, Germany. seidel@foodsci.uni-kiel.de.
Manfred EggersdorferDSM Nutritional Products, P.O. Box 2676, 4002 Basel, Switzerland. manfred.eggersdorfer@dsm.com.
Gerald RimbachInstitute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Straße 6, D-24118 Kiel, Germany. rimbach@foodsci.uni-kiel.de.
Tuba EsatbeyogluInstitute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Straße 6, D-24118 Kiel, Germany. esatbeyoglu@foodsci.uni-kiel.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astaxanthin is a coloring agent which is used as a feed additive in aquaculture nutrition. Recently, potential health benefits of astaxanthin have been discussed which may be partly related to its free radical scavenging and antioxidant properties. Our electron spin resonance (ESR) and spin trapping data suggest that synthetic astaxanthin is a potent free radical scavenger in terms of diphenylpicryl-hydrazyl (DPPH) and galvinoxyl free radicals. Furthermore, astaxanthin dose-dependently quenched singlet oxygen as determined by photon counting. In addition to free radical scavenging and singlet oxygen quenching properties, astaxanthin induced the antioxidant enzyme paroxoanase-1, enhanced glutathione concentrations and prevented lipid peroxidation in cultured hepatocytes. Present results suggest that, beyond its coloring properties, synthetic astaxanthin exhibits free radical scavenging, singlet oxygen quenching, and antioxidant activities which could probably positively affect animal and human health.

Indexed as

Cell LineFree Radical ScavengersHepatocytesHep G2 CellsHumansLipid PeroxidationXanthophyllsastaxanthineFree Radical ScavengersXanthophyllsantioxidantastaxanthinelectron spin resonance spectroscopyfree radical scavenging

Identifiers

PMID26784174
PMCPMC4730345

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.