ArticleMolecules (Basel, Switzerland)2016
Efficient Synthesis and Antibacterial Evaluation of (±)-Yanglingmycin and Its Analogues.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- The diversity and utility of arylthiazoline and aryloxazoline siderophores: challenges of total synthesis.RSC advances · 2022Review
- Structurally Diverse Sesquiterpenoids with Anti-neuroinflammatory Activity from the Endolichenic Fungus Cryptomarasmius aucubae.Natural products and bioprospecting · 2021Article
- Synthesis and In Vitro Antibacterial Activity of Quaternized 10-Methoxycanthin-6-one Derivatives.Molecules (Basel, Switzerland) · 2019Article
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8 authors.
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Abstract
An efficient synthetic route was developed for the large-scale preparation of (±)-Yanglingmycin and its analogues. Three series of derivatives of (±)-Yanglingmycin were synthesized and the structures of all compounds were elucidated by analyses of NMR and ESI-MS spectra data. Moreover, their antibacterial activities against seven species of bacteria were systematically evaluated by the micro-broth dilution method, most of which displayed considerable activity. It was worth noting that compounds 5b, 5c, 5d, 6g, and 7 were found to be the most promising leading candidates, with peak MIC values of 0.98 μg·mL(-1) for Bacillus subtilis, which is superior to positive controls (MIC = 3.91 μg·mL(-1)). The above results might lay the firm foundation for the design and synthesis of novel antibacterial drugs based on (±)-Yanglingmycin.
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