ReviewAntioxidants (Basel, Switzerland)2015
Which Is the Most Significant Cause of Aging?
Review in Antioxidants (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Antioxidant strategies against cellular senescence: unveiling the power of synthetic versus natural antioxidants in a systematic review.Frontiers in aging · 2025Pooled it
- Protective Effect of Carvacrol against Oxidative Damage in Aged Rats.Central nervous system agents in medicinal chemistry · 2025Article
- Cytoprotective Properties of Turmeric Oil (Curcuma longa L.) on Fibroblast Cells.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Article
- Review
- CNS Ageing in Health and Neurodegenerative Disorders.Journal of clinical medicine · 2023Review
- Autologous NK cells propagated and activatedBiochemistry and biophysics reports · 2022Article
- Review
- The intervention on aging system: A classification model, the requirement for five novel categories.Aging medicine (Milton (N.S.W)) · 2022Review
- Broadening the selection criteria for Astronauts undertaking long-term space travel.Frontiers in nuclear medicine · 2022Article
- Natural Deep Eutectic Extracts of Propolis,Oxidative medicine and cellular longevity · 2022Article
- Genomic instability in the naturally and prematurely aged myocardium.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Deficits in the vesicular acetylcholine transporter alter lifespan and behavior in adult Drosophila melanogaster.Neurochemistry international · 2020Article
- Metformin as Anti-Aging Therapy: Is It for Everyone?Trends in endocrinology and metabolism: TEM · 2019Review
- Evolution favours aging in populations with assortative mating and in sexually dimorphic populations.Scientific reports · 2018Article
- Molecular and biochemical evidence on the protective role of ellagic acid and silybin against oxidative stress-induced cellular aging.Molecular and cellular biochemistry · 2018Article
- Mitochondria: Central Organelles for Melatonin's Antioxidant and Anti-Aging Actions.Molecules (Basel, Switzerland) · 2018Review
- Erythropoietin suppresses D-galactose-induced aging of rats via the PI3K/Akt/Nrf2-ARE pathway.International journal of clinical and experimental pathology · 2018Article
- Risky repair: DNA-protein crosslinks formed by mitochondrial base excision DNA repair enzymes acting on free radical lesions.Free radical biology & medicine · 2017Review
- The Anti-Aging Effect of Erythropoietin via the ERK/Nrf2-ARE Pathway in Aging Rats.Journal of molecular neuroscience : MN · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It becomes clearer and clearer that aging is a result of a significant number of causes and it would seem that counteracting one or several of them should not make a significant difference. Taken at face value, this suggests, for example, that free radicals and reactive oxygen species do not play a significant role in aging and that the lifespan of organisms cannot be significantly extended. In this review, I point to the fact that the causes of aging synergize with each other and discuss the implications involved. One implication is that when two or more synergizing causes increase over time, the result of their action increases dramatically; I discuss a simple model demonstrating this. It is reasonable to conclude that this might explain the acceleration of aging and mortality with age. In this regard, the analysis of results and mortality patterns described in studies involving yeasts and Drosophila provides support for this view. Since the causes of aging are synergizing, it is also concluded that none of them is the major one but many including free radicals, etc. play significant roles. It follows that health/lifespan might be significantly extended if we eliminate or even attenuate the increase of a few or even just one of the causes of aging. While the synergism between the causes of aging is the main topic of this review, several related matters are briefly discussed as well.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.