ReviewSeminars in cell & developmental biology2016
Cis-regulatory programs in the development and evolution of vertebrate paired appendages.
Review in Seminars in cell & developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- A cetacean-specific CNE suppresses osteogenesis to drive appendicular modification in secondary aquatic adaptation.iScience · 2026Article
- Comparative analysis of conserved non-coding elements identifies gene regulatory networks rewired during the water-to-land transition in vertebrates.Biologia futura · 2026Article
- Ancient developmental genes underlie evolutionary novelties in walking fish.Current biology : CB · 2024Article
- Protein signaling and morphological development of the tail fluke in the embryonic beluga whale (Delphinapterus leucas).Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Splicing is dynamically regulated during limb development.Scientific reports · 2024Article
- Identification of ancestral gnathostome Gli3 enhancers with activity in mammals.Development, growth & differentiation · 2024Article
- The genetic basis of novel trait gain in walking fish.bioRxiv : the preprint server for biology · 2023Article
- Review
- Future Tail Tales: A Forward-Looking, Integrative Perspective on Tail Research.Integrative and comparative biology · 2021Review
- The bowfin genome illuminates the developmental evolution of ray-finned fishes.Nature genetics · 2021Article
- Evolutionary divergence of a Hoxa2b hindbrain enhancer in syngnathids mimics results of functional assays.Development genes and evolution · 2021Article
- Comparative genomic analysis of human GLI2 locus using slowly evolving fish revealed the ancestral gnathostome set of early developmental enhancers.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy.Nature communications · 2021Article
- Duplication of 10q24 locus: broadening the clinical and radiological spectrum.European journal of human genetics : EJHG · 2019Article
- Ancient mechanisms for the evolution of the bicoid homeodomain's function in fly development.eLife · 2018Article
- The rewiring of transcription circuits in evolution.Current opinion in genetics & development · 2017Review
- John Saunders' ZPA, Sonic hedgehog and digit identity - How does it really all work?Developmental biology · 2017Review
- Saunders's framework for understanding limb development as a platform for investigating limb evolution.Developmental biology · 2017Review
- The Conserved Sonic Hedgehog Limb Enhancer Consists of Discrete Functional Elements that Regulate Precise Spatial Expression.Cell reports · 2017Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Differential gene expression is the core of development, mediating the genetic changes necessary for determining cell identity. The regulation of gene activity by cis-acting elements (e.g., enhancers) is a crucial mechanism for determining differential gene activity by precise control of gene expression in embryonic space and time. Modifications to regulatory regions can have profound impacts on phenotype, and therefore developmental and evolutionary biologists have increasingly focused on elucidating the transcriptional control of genes that build and pattern body plans. Here, we trace the evolutionary history of transcriptional control of three loci key to vertebrate appendage development (Fgf8, Shh, and HoxD/A). Within and across these regulatory modules, we find both complex and flexible regulation in contrast with more fixed enhancers that appear unchanged over vast timescales of vertebrate evolution. The transcriptional control of vertebrate appendage development was likely already incredibly complex in the common ancestor of fish, implying that subtle changes to regulatory networks were more likely responsible for alterations in phenotype rather than the de novo addition of whole regulatory domains. Finally, we discuss the dangers of relying on inter-species transgenesis when testing enhancer function, and call for more controlled regulatory swap experiments when inferring the evolutionary history of enhancer elements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.