ArticleAntioxidants (Basel, Switzerland)2015
Quercetin, a Flavonoid Antioxidant, Ameliorated Procarbazine-Induced Oxidative Damage to Murine Tissues.
Article in Antioxidants (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Randomized Clinical Trial: Bergamot Citrus and Wild Cardoon Reduce Liver Steatosis and Body Weight in Non-diabetic Individuals Aged Over 50 Years.Frontiers in endocrinology · 2020Trial
- The integration of network pharmacology and multiomics reveals the mechanism by which Malus hupehensis leaves inhibit acute liver injury.BMC complementary medicine and therapies · 2026Article
- Flavonoids from Polygonum hydropiper L. regulate PCV2-induced oxidative stress of RAW264.7 cells via Pi3k/AKT and Nrf2/HO-1 signaling pathways.Scientific reports · 2025Article
- Protective effects of omega-3 against procarbazine-induced brain damage in the cerebellum and CA1 Hippocampus of male rats: a focus on oxidative stress mechanisms.Metabolic brain disease · 2025Article
- Article
- [Mechanisms mediating the inhibitory effects of quercetin against phthalates-induced testicular oxidative damage in rats].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Targeting Oxidative Stress Markers, Xanthine Oxidase, TNFRSF11A and Cathepsin L in Curcumin-Treated Collagen-Induced Arthritis: A Physiological and COSMO-RS Study.Inflammation · 2023Article
- Revisiting treatment-related cardiotoxicity in patients with malignant lymphoma-a review and prospects for the future.Frontiers in cardiovascular medicine · 2023Review
- Inhibitory Effect and Mechanism of Action of Quercetin and Quercetin Diels-AlderAntioxidants (Basel, Switzerland) · 2020Article
- Protective Effects of Quercetin on Livers from Mice Exposed to Long-Term Cigarette Smoke.BioMed research international · 2020Article
- Article
- Dietary Flavonoids as Cancer Chemopreventive Agents: An Updated Review of Human Studies.Antioxidants (Basel, Switzerland) · 2019Review
- Effects of quercetin on bisphenol A-induced mitochondrial toxicity in rat liver.Iranian journal of basic medical sciences · 2019Article
- Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application.Molecules (Basel, Switzerland) · 2019Review
- Quality Control of the Root and Rhizome of Helminthostachys zeylanica (Daodi-Ugon) by HPLC Using Quercetin and Ugonins as Markers.Molecules (Basel, Switzerland) · 2017Article
- Can Omegaven Avoid the Destructive Effect of Procarbazine Over Ovarian Reserve?Reproductive medicine and biologyArticle
- The role of flavonoid antioxidant, morin in improving procarbazine-induced oxidative stress on testicular function in rat.Porto biomedical journalArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Procarbazine (PCZ) (indicated in Hodgkin's disease), is an alkylating agent known to generate free radicals in vivo, while Quercetin (QCT) is a flavonoid antioxidant with proven free radical scavenging capacity. This study investigated the protective effects of QCT on PCZ-induced oxidative damage in the rat. Male Wistar rats (160-180 g) were randomized into five groups (n = 5/group): I (control), II PCZ-treated (2 mg/kg body weight (bw) for seven days); III pre-treated with QCT (20 mg/kg bw) for seven days, followed by PCZ for seven days; IV co-treated with PCZ and QCT for seven days and V administered QCT alone for seven days. PCZ caused a significant increase in plasma total bilirubin, urea, and creatinine when compared with control (P < 0.05). Similarly, plasma activities of alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transferase (γ-GT) were significantly increased in the PCZ-treated group relative to control. Furthermore, PCZ caused a significant decrease in the activities of hepatic superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) as well as levels of ascorbic acid (AA) and glutathione (GSH). This was followed by a significant increase in hepatic malondialdehyde (MDA) content. However, QCT pre-treatment and co-treatment ameliorated the PCZ-induced changes in plasma levels of urea, creatinine, and bilirubin as well as the activities of ALP, AST, ALT, and GGT. QCT also ameliorated hepatic AA and GSH levels and the activities of SOD, CAT, and GST. This all suggests that QCT protected against PCZ-induced oxidative damage in rats.
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