Evidence map›Paper›PMID 26783558›Full record

ArticleACS infectious diseases2015

Leah S Imlay, Christopher M Armstrong, Mary Clare Masters, Ting Li, Kathryn E Price, Rachel L Edwards, Katherine M Mann, Lucy X Li, Christina L Stallings, Neil G Berry and 2 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. TargetingJournal of medicinal chemistry · 2024
    Article
  6. Article
  7. Antimalarial drug discovery: progress and approaches.Nature reviews. Drug discovery · 2023
    Review
  8. Review
  9. Article
  10. Article
  11. Malaria Box-Inspired Discovery ofACS medicinal chemistry letters · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Leah S ImlayDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Christopher M ArmstrongDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Mary Clare MastersDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Ting LiCollege of Medicine, University of Toledo, Toledo, Ohio 43614, United States.
Kathryn E PriceDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.
Rachel L EdwardsDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Katherine M MannDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Lucy X LiDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Christina L StallingsDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Neil G BerryDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.
Paul M O'NeillDepartment of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.
Audrey R OdomDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, United States.
Washington University in St. Louis · USUniversity of Liverpool · GBUniversity of Toledo · US

Funding

NATIONAL RESEARCH SERVICE AWARD-MEDICAL SCIENTISTT32GM007200 · NIGMS · WASHINGTON UNIVERSITY · PI YOKOYAMA, WAYNE M. · 1985 to 2024
$59.8M
Infectious Diseases/Basic Microbial Pathogenic MechanismsT32AI007172 · NIAID · WASHINGTON UNIVERSITY · PI Daniel E. Goldberg, JENNIFER A PHILIPS · 1985 to 2026
$13.0M
MEP pathway resistance in Plasmodium falciparumR01AI103280 · NIAID · WASHINGTON UNIVERSITY · PI Audrey Ragan Odom John · 2013 to 2026
$5.5M
GE AKTAEXPLORER CHROMOTOGRAPHY SYSTEMS10RR026891 · NCRR · WASHINGTON UNIVERSITY · PI ODOM JOHN, AUDREY RAGAN · 2010 to 2010
$122k
NCRR NIH HHS S10 RR026891NIAID NIH HHS R01 AI103280NIAID NIH HHS T32 AI007172NIGMS NIH HHS T32 GM007200
6 · The paper itself

Abstract

As resistance to current therapies spreads, novel antimalarials are urgently needed. In this work, we examine the potential for therapeutic intervention via the targeting of

Indexed as

homology modelIspDmalariaMEP pathwayMMV008138plasmodium

Identifiers

PMID26783558
PMCPMC4714788
OpenAlexW2315422056

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.