ReviewInternational journal of dentistry2015
Photodynamic Antimicrobial Chemotherapy for Root Canal System Asepsis: A Narrative Literature Review.
Review in International journal of dentistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Effect of diode laser pretreatment on dentin thickness and discoloration in deep caries treated with biodentine: a randomized clinical trial.Scientific reports · 2026Trial
- Exploring and Anticipating the Applications of Organic Room-Temperature Phosphorescent Materials in Biomedicine and Dentistry.International journal of nanomedicine · 2024Review
- Antimicrobial photodynamic therapy using a low-power 650 nm laser to inhibit oralJournal of medicine and life · 2024Article
- Photobiomodulation Therapy and Pulp-Regenerative Endodontics: A Narrative Review.Bioengineering (Basel, Switzerland) · 2023Review
- Reactive Oxygen Species Enlightened Therapeutic Strategy for Oral and Maxillofacial Diseases-Art of Destruction and Reconstruction.Biomedicines · 2022Review
- Visible Lights Combined with Photosensitizing Compounds Are Effective against Candida albicans Biofilms.Microorganisms · 2021Article
- Enzyme-Responsive Materials as Carriers for Improving Photodynamic Therapy.Frontiers in chemistry · 2021Review
- Learning from Nature: Bioinspired Chlorin-Based Photosensitizers Immobilized on Carbon Materials for Combined Photodynamic and Photothermal Therapy.Biomimetics (Basel, Switzerland) · 2020Review
- Antimicrobial Prosthetic Surfaces in the Oral Cavity-A Perspective on Creative Approaches.Microorganisms · 2020Review
- Focal Infection and Periodontitis: A Narrative Report and New Possible Approaches.International journal of microbiology · 2020Review
- An Insight into Advanced Approaches for Photosensitizer Optimization in Endodontics-A Critical Review.Journal of functional biomaterials · 2019Article
- Revisiting Current Photoactive Materials for Antimicrobial Photodynamic Therapy.Molecules (Basel, Switzerland) · 2018Review
- Light Activated Disinfection in Root Canal Treatment-A Focused Review.Dentistry journal · 2018Review
- Generation and Role of Reactive Oxygen and Nitrogen Species Induced by Plasma, Lasers, Chemical Agents, and Other Systems in Dentistry.Oxidative medicine and cellular longevity · 2017Review
- Antimicrobial Photodynamic Therapy against EndodonticFrontiers in microbiology · 2017Article
- Antimicrobial efficacy of different concentration of sodium hypochlorite on the biofilm ofJournal of clinical and experimental dentistry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim. The aim of this comprehensive literature review was to address the question: Does photodynamic therapy (PDT) improve root canal disinfection through significant bacterial reduction in the root canal system? Methodology. A comprehensive narrative literature review was performed to compare PDT effect with sodium hypochlorite as the comparative classical irrigant. Two reviewers independently conducted literature searches using a combination of medical subject heading terms and key words to identify relevant studies comparing information found in 7 electronic databases from January 2000 to May 2015. A manual search was performed on bibliography of articles collected on electronic databases. Authors were contacted to ask for references of more research not detected on the prior electronic and manual searches. Results. The literature search provided 62 titles and abstracts, from which 29 studies were related directly to the search theme. Considering all publications, 14 (48%) showed PDT to be more efficient in antimicrobial outcome than NaOCl (0.5-6% concentration) used alone and 2 (7%) revealed similar effects between them. Toluidine blue and methylene blue are the most used photosensitizers and most commonly laser has 660 nm of wavelength with a 400 nm diameter of intracanal fiber. Conclusions. PDT has been used without a well-defined protocol and still remains at an experimental stage waiting for further optimization. The level of evidence available in clinical studies to answer this question is low and at high risk of bias.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.