ArticleInternational journal of stroke : official journal of the International Stroke Society2016
Intracranial plaque enhancement from high resolution vessel wall magnetic resonance imaging predicts stroke recurrence.
Article in International journal of stroke : official journal of the International Stroke Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 72 papers, 9 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PCSK9 Inhibition in Patients With Symptomatic Intracranial Atherosclerosis
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging
Plaque Characteristics From Vessel Wall Magnetic Resonance Imaging Predict Recurrent Stroke in Ischemic Stroke Patients Due to Middle Cerebral Artery Stenosis
Who cites it
72 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- A systematic review of intracranial atherosclerosis epidemiology-the largest contributor to the global ischemic stroke burden?Frontiers in neurology · 2026Pooled it
- Intracranial atherosclerotic plaque features on vessel wall imaging predict first ever and recurrence of stroke: a meta-analysis.European radiology · 2025Pooled it
- High-risk plaque characteristics associated with recurrent stroke in patients with intracranial stenosis: a systematic review and meta-analysis.Journal of neurology · 2025Pooled it
- Imaging endpoints of intracranial atherosclerosis using vessel wall MR imaging: a systematic review.Neuroradiology · 2021Pooled it
- Vessel Wall Magnetic Resonance Imaging Biomarkers of Symptomatic Intracranial Atherosclerosis: A Meta-Analysis.Stroke · 2021Pooled it
- Qualitative Assessment and Reporting Quality of Intracranial Vessel Wall MR Imaging Studies: A Systematic Review.AJNR. American journal of neuroradiology · 2019Pooled it
- Culprit intracranial plaque without substantial stenosis in acute ischemic stroke on vessel wall MRI: A systematic review.Atherosclerosis · 2019Pooled it
- Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017.Stroke and vascular neurology · 2018Guideline
- Gadolinium Enhancement in Intracranial Atherosclerotic Plaque and Ischemic Stroke: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2016 · on this mapPooled it
- Intracranial Plaque Characteristics and Extracranial Carotid Plaque-RADS Associated With Stroke Recurrence: A High-Resolution Vessel Wall Imaging Study.Journal of magnetic resonance imaging : JMRI · 2026Article
- Differentiated risk factors for stroke recurrence in anterior versus posterior circulation intracranial atherosclerosis: A high-resolution vessel wall imaging study.Neuroimage. Reports · 2026Article
- Plaque phenotypes across remodeling patterns in vertebrobasilar atherosclerosis: a high-resolution magnetic resonance vessel wall imaging study.Quantitative imaging in medicine and surgery · 2026Article
- Correlation Between Serum TGF-β1 Levels, Intracranial Atherosclerotic Plaque Parameters and Post-Stroke Cognitive Impairment.International journal of general medicine · 2026Article
- Observational
- Arterial wall enhancement on high-resolution vessel-wall MRI correlates with stenosis burden and large-artery atherosclerosis subtype in ischemic stroke.Neurosurgical review · 2025Article
- Voxel-Wise Quantification and Multi-planar Visualization of Plaque Contrast Enhancement in Intracranial Vessel Wall MRI.medRxiv : the preprint server for health sciences · 2025Article
- Inter-rater reliability of atherosclerotic plaque enhancement on 7 T vessel wall MRI: Comparison with quantitative analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- MRI-based habitat radiomics combined with vision transformer for identifying vulnerable intracranial atherosclerotic plaques and predicting stroke events: a multicenter, retrospective study.EClinicalMedicine · 2025Article
- Association between perforator stroke after middle cerebral artery elective stenting and arterial remodeling patterns: a high-resolution MRI-based retrospective cohort study.Quantitative imaging in medicine and surgery · 2024Article
- Role of Vessel Wall Magnetic Resonance Imaging in the Diagnosis of Intracranial Vasculopathies.Cureus · 2024Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntracranial atherosclerosis is associated with frequent stroke recurrence. High resolution vessel wall magnetic resonance imaging (HRMRI) can provide atheroma information related to its vulnerability.
aimsWe performed HRMRI in stroke patients with intracranial atherosclerosis to determine whether plaque characteristics from vessel wall imaging can predict future stroke recurrence.
methodsBetween July 2011 and June 2013, acute stroke patients with symptomatic intracranial atherosclerosis were prospectively enrolled and 3-tesla HRMRI was performed on the relevant artery. The plaque enhancement was visually determined from T1 post-gadolinium enhancement image. Stroke recurrence was monitored after index event and multivariate Cox proportional hazards model was constructed to identify factors related to future stroke recurrence.
resultsA total of 138 patients were included with a median follow-up of 18 months. There were 39 stroke recurrences. Plaque enhancement was detected in 108 patients (78.3%), and 37 of them experienced stroke recurrence. Among 30 stroke patients without plaque enhancement, two patients experienced stroke recurrence. Kaplan-Meier curves demonstrated a significant difference in event free survival between the patients with plaque enhancement and those patients without plaque enhancement (event rates at year 1: 30.3% vs. 6.8%, log-rank test, p = 0.004). Multivariate Cox-regression analysis showed that the plaque enhancement from HRMRI was independently associated with stroke recurrence (hazard ratio: 7.42, 95% confidence interval: 1.74-31.75, p = 0.007).
conclusionIntracranial plaque enhancement from HRMRI is associated with stroke recurrence among the patients with symptomatic intracranial atherosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.