ArticleNature communications2016
Mutational spectrum of Barrett's stem cells suggests paths to initiation of a precancerous lesion.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Esophageal cancer: from pathogenesis to precision therapies.Signal transduction and targeted therapy · 2026Review
- Advancing Esophageal Disease Modeling: Microfluidic Platforms for Adult Tissue-Resident Stem Cell Culture and Differentiation.Gastro hep advances · 2026Article
- Evolution of Esophageal Adenocarcinoma From Precursor Lesion Stem Cells.Gastroenterology · 2025Article
- Chemically-defined and scalable culture system for intestinal stem cells derived from human intestinal organoids.Nature communications · 2024Article
- Mapping the adult human esophagus in vivo and in vitro.Development (Cambridge, England) · 2022Article
- Article
- A human Barrett's esophagus organoid system reveals epithelial-mesenchymal plasticity induced by acid and bile salts.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- E-Cigarette Aerosol Exposure Favors the Growth and Colonization of Oral Streptococcus mutans Compared to Commensal Streptococci.Microbiology spectrum · 2022Article
- Intrinsic Cellular Susceptibility to Barrett's Esophagus in Adults Born with Esophageal Atresia.Cancers · 2022Article
- A new murine esophageal organoid culture method and organoid-based model of esophageal squamous cell neoplasia.iScience · 2021Article
- HOXA13 in etiology and oncogenic potential of Barrett's esophagus.Nature communications · 2021Article
- Article
- Cloning of ground-state intestinal stem cells from endoscopic biopsy samples.Nature protocols · 2020Article
- [Concept and research progress of precancerous lesions].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2020Article
- Esophageal Tumor Microenvironment.Advances in experimental medicine and biology · 2020Review
- High Content Imaging of Barrett's-Associated High-Grade Dysplasia Cells After siRNA Library Screening Reveals Acid-Responsive Regulators of Cellular Transitions.Cellular and molecular gastroenterology and hepatology · 2020Article
- Low-Level Mouse DNA in Conditioned Medium Generates False Positive Cross-Species Contamination Results in Human Organoid Cultures.Frontiers in cell and developmental biology · 2020Article
- Microenvironment meets lineage complexity in junctional tumorigenesis.Nature communications · 2019Article
- The cyclical hit model: how paligenosis might establish the mutational landscape in Barrett's esophagus and esophageal adenocarcinoma.Current opinion in gastroenterology · 2019Review
- Identification of a primitive intestinal transcription factor network shared between esophageal adenocarcinoma and its precancerous precursor state.Genome research · 2019Article
Corrections and comments
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Authors and funding
21 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The precancerous lesion known as Barrett's oesophagus can evolve to oesophageal adenocarcinoma in decades-long processes of regenerative growth. Here we report the isolation and propagation of distinct, patient-matched stem cells of Barrett's, gastric and oesophageal epithelia that yield divergent tumour types following in vitro transformation and xenografting. Genomic analyses reveal a broad mutational spectrum unique to Barrett's stem cells that likely reflects their risk for oncogenesis. Remarkably, 25% of cases show no cancer-related genomic changes, suggesting that Barrett's initiates without driver mutations. Most cases, however, sustain patterns of deletions almost identical to adenocarcinoma though tumour-associated gene amplifications were absent. Notably, those suspected of low-grade dysplasia have p53 mutations or undergo amplifications of proto-oncogenes and receptor tyrosine kinases, implicating these events in lethal transitions. Our findings suggest paths for the initiation and progression of Barrett's and define a discrete stem cell underlying its regenerative growth whose eradication could prevent oesophageal adenocarcinoma.
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