Evidence map›Paper›PMID 26783091›Full record

ArticleNature communications2016

Bioabsorbable polymer optical waveguides for deep-tissue photomedicine.

Sedat Nizamoglu, Malte C Gather, Matjaž Humar, Myunghwan Choi, Seonghoon Kim, Ki Su Kim, Sei Kwang Hahn, Giuliano Scarcelli, Mark Randolph, Robert W Redmond and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

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  8. Low-Irradiance Antimicrobial Blue Light-Bathing Therapy for Wound Infection Control.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sedat NizamogluWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 65 Landsdowne Street UP-5, Cambridge, Massachusetts 02139, USA.
Malte C GatherWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 65 Landsdowne Street UP-5, Cambridge, Massachusetts 02139, USA.
Matjaž HumarWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 65 Landsdowne Street UP-5, Cambridge, Massachusetts 02139, USA.
Myunghwan ChoiWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 65 Landsdowne Street UP-5, Cambridge, Massachusetts 02139, USA.ORCID http://orcid.org/0000-0002-4235-7003
Seonghoon KimGraduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, 291 Daehakro, Yuseong, Daejeon 305-701, Korea.
Ki Su KimWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 65 Landsdowne Street UP-5, Cambridge, Massachusetts 02139, USA.
Sei Kwang HahnDepartment of Materials Science and Engineering, Pohang University of Science and Technology, San 31, Hyoja-dong, Nam, Pohang, Kyungbuk 790-784, Korea.
Giuliano ScarcelliWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 65 Landsdowne Street UP-5, Cambridge, Massachusetts 02139, USA.
Mark RandolphWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 65 Landsdowne Street UP-5, Cambridge, Massachusetts 02139, USA.
Robert W RedmondWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 65 Landsdowne Street UP-5, Cambridge, Massachusetts 02139, USA.
Seok Hyun YunWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, 65 Landsdowne Street UP-5, Cambridge, Massachusetts 02139, USA.

Funding

TRD3: Percutaneous and Interstitial ImagingP41EB015903 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Brett E Bouma · 2012 to 2026
$22.4M
Bioluminecence-activated photodynamic therapy of breast cancerR01CA192878 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI YUN, SEOK-HYUN ANDY · 2015 to 2019
$2.3M
Biocompatible OpticsR21EB013761 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI YUN, SEOK-HYUN ANDY · 2011 to 2012
$479k
NCI NIH HHS R01 CA192878NCI NIH HHS R01CA192878NIBIB NIH HHS P41 EB015903NIBIB NIH HHS P41EB015903NIBIB NIH HHS R21 EB013761NIBIB NIH HHS R21EB013761
6 · The paper itself

Abstract

Advances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. Here we show implantable light-delivery devices made of bio-derived or biocompatible, and biodegradable polymers. In contrast to conventional optical fibres, which must be removed from the body soon after use, the biodegradable and biocompatible waveguides may be used for long-term light delivery and need not be removed as they are gradually resorbed by the tissue. As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bonding (PTB). Using comb-shaped planar waveguides, we achieve a full thickness (>10 mm) wound closure of porcine skin, which represents ∼ 10-fold extension of the tissue area achieved with conventional PTB. The results point to a new direction in photomedicine for using light in deep tissues.

Indexed as

Absorbable ImplantsMedicinePhotochemistryPolymersPolymers

Identifiers

PMID26783091
PMCPMC4735646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.