ReviewPediatric surgery international2016
Established and emerging concepts in Hirschsprung's-associated enterocolitis.
Review in Pediatric surgery international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Longitudinal analysis of gut microbiota dysbiosis and bacterial signatures predictive of postoperative enterocolitis in children with Hirschsprung disease.Clinical and experimental pediatrics · 2026Article
- Post-Surgical Gut Microbiota Alterations in Pediatric Patients with Intestinal Disorders.Journal of clinical medicine · 2026Review
- Review
- Postoperative Hirschsprung's associated enterocolitis (HAEC): transition zone as putative histopathological predictive factor.Journal of clinical pathology · 2025Article
- 16S rRNA Sequencing Reveals Alterations of Gut Bacteria in Hirschsprung-Associated Enterocolitis.Global medical genetics · 2024Article
- The mediating role of metabolites between gut microbiome and Hirschsprung disease: a bidirectional two-step Mendelian randomization study.Frontiers in pediatrics · 2024Article
- Hirschsprung's disease associated enterocolitis: A comprehensive review.World journal of clinical pediatrics · 2023Review
- Prognostic factors of postoperative Hirschsprung-associated enterocolitis: a cohort study.Pediatric surgery international · 2023Article
- Risk factors for Hirschsprung-associated enterocolitis following Soave: a retrospective study over a decade.BMC pediatrics · 2022Article
- A Novel Method for Identifying the Transition Zone in Long-Segment Hirschsprung Disease: Investigating the Muscle Unit to Ganglion Ratio.Biomolecules · 2022Article
- Different Fecal Microbiota in Hirschsprung's Patients With and Without Associated Enterocolitis.Frontiers in microbiology · 2022Article
- Identification and validation of the common pathogenesis and hub biomarkers in Hirschsprung disease complicated with Crohn's disease.Frontiers in immunology · 2022Article
- Alterations of Gut Bacteria in Hirschsprung Disease and Hirschsprung-Associated Enterocolitis.Microorganisms · 2021Review
- Reducing Underdiagnosis of Hirschsprung-Associated Enterocolitis: A Novel Scoring System.The Journal of surgical research · 2021Article
- The enteric nervous system in gastrointestinal disease etiology.Cellular and molecular life sciences : CMLS · 2021Review
- Predictive factors for the development of postoperative Hirschsprung-associated enterocolitis in children operated during infancy.Pediatric surgery international · 2021Article
- Inpatient management of Hirschsprung's associated enterocolitis treatment: the benefits of standardized care.Pediatric surgery international · 2020Article
- Postoperative enterocolitis assessment using two different cut-off values in the HAEC score in Hirschsprung patients undergoing Duhamel and Soave pull-through.BMC pediatrics · 2020Article
- 37/67-laminin receptor facilitates neural crest cell migration during enteric nervous system development.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Innate and Adaptive Immunity Linked to Recognition of Antigens Shared by Neural Crest-Derived Tumors.Cancers · 2020Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Hirschsprung's disease (HSCR) is a common cause of neonatal bowel obstruction and the approach to diagnosis and surgical treatment is well defined and accepted. Hirschsprung's-associated enterocolitis (HAEC) remains a frequent cause of pre-operative and post-operative morbidity and mortality, with unchanged treatment guidelines over multiple decades. Recent advances in our understanding of the genetics underlying HSCR have allowed the development of animal models, some of which recapitulate the HAEC phenotype. These animal models, along with recent translational studies, have implicated multiple facets of mucosal immunity and microbiome dysbiosis in the development of HAEC. Here, we will review the established epidemiology, modes of diagnosis and treatment of HAEC. Furthermore, we will explore emerging concepts in the pathogenesis of this disease; including animal models, alterations in mucosal immunity, dysbiosis of the intestinal microbiome, specific genetic susceptibility, and novel treatment modalities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.