Evidence map›Paper›PMID 26783083›Full record

ArticleCancer medicine2016

The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk.

Jessica Becker, Andrea May, Christian Gerges, Mario Anders, Claudia Schmidt, Lothar Veits, Tania Noder, Rupert Mayershofer, Nicole Kreuser, Hendrik Manner and 34 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. A Deletion inGenes · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors at 18 institutions in 2 countries.

Jessica BeckerInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Andrea MayDepartment of Medicine II, Sana Klinikum, Offenbach, Germany.
Christian GergesDepartment of Internal Medicine II, Evangelisches Krankenhaus, Düsseldorf, Germany.
Mario AndersDepartment of Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Claudia SchmidtDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany.
Lothar VeitsInstitute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.
Tania NoderDepartment of Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Rupert MayershoferGastroenterologie am Burgweiher, Bonn, Germany.
Nicole KreuserDepartment of Visceral Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.
Hendrik MannerDepartment of Internal Medicine II, HSK Hospital, Wiesbaden, Germany.
Marino VeneritoDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany.
Jan-Hinnerk HoferMagen Darm Zentrum Wiener Platz, Cologne, Germany.
Orestis LyrosDepartment of Visceral Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.
Constantin J AhlbrandDepartment of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany.
Michael ArrasDepartment of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany.
Sebastian HoferDepartment of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany.
Sophie K M HeinrichsInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Katharina WeiseInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Timo HessInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Anne C BöhmerInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Nils KosiolInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Ralf KiesslichDepartment of Internal Medicine II, HSK Hospital, Wiesbaden, Germany.
Jakob R IzbickiDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany.
Arnulf H HölscherDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany.
Elfriede BollschweilerDepartment of General, Visceral and Cancer Surgery, University of Cologne, Cologne, Germany.
Peter MalfertheinerDepartment of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Hospital, Magdeburg, Germany.
Hauke LangDepartment of General, Visceral and Transplant Surgery, University Medical Center, University of Mainz, Mainz, Germany.
Markus MoehlerFirst Department of Internal Medicine, University Medical Center, University of Mainz, Mainz, Germany.
Dietmar LorenzDepartments of General and Visceral Surgery, Sana Klinikum, Offenbach, Germany.
Katja OttDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.
Thomas SchmidtDepartment of General, Visceral and Thorax Surgery, RoMed Klinikum Rosenheim, Rosenheim, Germany.
Markus M NöthenInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Andreas HackelsbergerGastropraxis, Wiesbaden, Germany.
Brigitte SchumacherDepartment of Internal Medicine II, Evangelisches Krankenhaus, Düsseldorf, Germany.
Oliver PechDepartments of Gastroenterology and Interventional Endoscopy, St. John of God Hospital, Regensburg, Germany.
Yogesh VashistDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, University of Hamburg, Hamburg, Germany.
Michael ViethInstitute of Pathology, Klinikum Bayreuth, Bayreuth, Germany.
Josef WeismüllerGastroenterologische Gemeinschaftspraxis, Koblenz, Germany.
Michael KnappInstitute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany.
Horst NeuhausDepartment of Internal Medicine II, Evangelisches Krankenhaus, Düsseldorf, Germany.
Thomas RöschDepartment of Interdisciplinary Endoscopy, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Christian EllDepartment of Medicine II, Sana Klinikum, Offenbach, Germany.
Ines GockelDepartment of Visceral Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.
Johannes SchumacherInstitute of Human Genetics, University of Bonn, Bonn, Germany.
Life & Brain (Germany) · DEUniversity of Bonn · DEEvangelisches Krankenhaus Düsseldorf · DEJohannes Gutenberg University Mainz · DESana Klinikum Offenbach · DEUniversity Hospital Leipzig · DEUniversity Medical Center Hamburg-Eppendorf · DEUniversity of Cologne · DEBayreuth Medical Center · DERoMed Kliniken · DESt. Marien Hospital · DEUniversität Hamburg · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DEInstitut für Medizinische Biometrie, Informatik und Epidemiologie · DEOtto-von-Guericke University Magdeburg · DEPraxis für Humangenetik · DEUniversity Hospital Magdeburg · DEUniversity Hospital Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) represent two stages within the esophagitis-metaplasia-dysplasia-adenocarcinoma sequence. Previously genetic risk factors have been identified that confer risk to BE and EAC development. However, to which extent the genetic variants confer risk to different stages of the BE/EAC sequence remains mainly unknown. In this study we analyzed three most recently identified BE variants at the genes GDF7 (rs3072), TBX5 (rs2701108), and ALDH1A2 (rs3784262) separately in BE and EAC samples in order to determine their risk effects during BE/EAC sequence. Our data show that rs3072 at GDF7 and rs2701108 at TBX5 are also associated with EAC and conclude that both loci confer disease risk also at later stages of the BE/EAC sequence. In contrast, rs3784262 at ALDH1A2 was highly significantly associated with BE, but showed no association with EAC. Our data do not provide evidence that the ALDH1A2 locus confers equal risk in early and late stages of BE/EAC sequence.

Indexed as

AdenocarcinomaBarrett EsophagusBone Morphogenetic ProteinsCase-Control StudiesDisease ProgressionEsophageal NeoplasmsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGrowth Differentiation FactorsHumansMaleNeoplasm ProteinsPolymorphism, Single NucleotidePrecancerous ConditionsRisk FactorsBone Morphogenetic ProteinsGDF7 protein, humanGrowth Differentiation FactorsNeoplasm ProteinsT-Box Domain ProteinsT-box transcription factor 5ALDH1A2Esophageal adenocarcinomaGDF7genetic association studyTBX5

Identifiers

PMID26783083
PMCPMC4864818
OpenAlexW2293942569

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.