Evidence map›Paper›PMID 26782995›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2016

Bone healing in rabbit calvarial critical-sized defects filled with stem cells and growth factors combined with granular or solid scaffolds.

Olli-Pekka Lappalainen, Sakari Karhula, Marianne Haapea, Laura Kyllönen, Suvi Haimi, Susanna Miettinen, Simo Saarakkala, Jarkko Korpi, Leena P Ylikontiola, Willy S Serlo and 1 more

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

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  8. Acceleration of osteogenesis by platelet-rich plasma with acellular dermal matrix in a calvarial defect model.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Olli-Pekka LappalainenDepartment of Oral and Maxillofacial Surgery, Oulu University Hospital and Medical Research Center, University of Oulu, Oulu, Finland.
Sakari KarhulaResearch Group of Medical Imaging, Physics and Technology, Infotech Doctoral Program, University of Oulu, Oulu, Finland.
Marianne HaapeaDepartment of Diagnostic Radiology, University of Oulu, Oulu, Finland.
Laura KyllönenBioMediTech, Institute of Biosciences and Medical Technology, University of Tampere, Tampere, Finland.
Suvi HaimiBioMediTech, Institute of Biosciences and Medical Technology, University of Tampere, Tampere, Finland.
Susanna MiettinenBioMediTech, Institute of Biosciences and Medical Technology, University of Tampere, Tampere, Finland.
Simo SaarakkalaResearch Group of Medical Imaging, Physics and Technology, Infotech Doctoral Program, Department of Diagnostic Radiology, Medical Research Center, University of Oulu, Oulu, Finland.
Jarkko KorpiDepartment of Otolaryngology, Head and Neck Surgery, Oulu University Hospital, Oulu, Finland.
Leena P YlikontiolaDepartment of Oral and Maxillofacial Surgery, Oulu University Hospital and Medical Research Center, University of Oulu, Oulu, Finland.
Willy S SerloDepartment of Children and Adolescents, Division of Pediatric Surgery, Oulu University Hospital, Medical Research Center, PEDEGO Research Center, University of Oulu, Oulu, Finland.
George K SándorDepartment of Oral and Maxillofacial Surgery, Oulu University Hospital and Medical Research Center, University of Oulu, Oulu, Finland. george.sandor@oulu.fi.
University of Oulu · FIOulu University Hospital · FITampere University · FITampere University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn pediatric neurosurgery, decompressive craniectomy and correction of congenital cranial anomalies can result in major cranial defects. Corrective cranioplasty for the repair of these critical-sized defects is not only a cosmetic issue. The limited availability of suitable autogenous bone and the morbidity of donor site harvesting have driven the search for new approaches with biodegradable and bioactive materials. This study aimed to assess the healing of rabbit calvarial critical-sized defects filled with osteogenic material, either with bioactive glass scaffolds or tricalcium phosphate granules in various combinations with adipose stem cells or bone marrow stem cells, BMP-2, BMP-7, or VEGF to enhance osteogenesis.

methodsEighty-two bicortical full thickness critical-sized calvarial defects were operated. Five defects were left empty as negative control defects. The remaining 77 defects were filled with solid bioactive glass scaffolds or tricalcium phosphate granules seeded with adipose or bone marrow derived stem cells in combination with BMP-2, BMP-7, or VEGF. The defects were allowed to heal for 6 weeks before histologic and micro-CT analyses.

resultsMicro-CT examination at the 6-week post-operative time point revealed that defects filled with stem cell-seeded tricalcium phosphate granules resulted in new bone formation of 6.0 %, whereas defects with bioactive glass scaffolds with stem cells showed new bone formation of 0.5 to 1.7 %, depending on the growth factor used.

conclusionsThis study suggests that tricalcium phosphate granules combined with stem cells have osteogenic potential superior to solid bioactive glass scaffolds with stem cells and growth factors.

Indexed as

Tissue ScaffoldsAnimalsBone DiseasesBone Morphogenetic Protein 2Bone Morphogenetic Protein 7Disease Models, AnimalHumansHydroxyapatitesIntercellular Signaling Peptides and ProteinsMaleRabbitsStem CellsTomography Scanners, X-Ray ComputedTreatment OutcomeVascular Endothelial Growth Factor AWound HealingBMP2 protein, humanBMP7 protein, humanBoneCeramicBone Morphogenetic Protein 2Bone Morphogenetic Protein 7HydroxyapatitesIntercellular Signaling Peptides and ProteinsVascular Endothelial Growth Factor ABone healingCranial defectMicro-CTStem cells

Identifiers

PMID26782995
OpenAlexW2276932119

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.