Trial reportJournal of the American Geriatrics Society2016
Exercise Mode Moderates the Relationship Between Mobility and Basal Ganglia Volume in Healthy Older Adults.
Trial report in Journal of the American Geriatrics Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Neural Correlates of Balance Skill Learning in Young and Older Individuals: A Systematic Review and Meta-analysis.Sports medicine - open · 2024Pooled it
- A Critical Systematic Review of Current Evidence on the Effects of Physical Exercise on Whole/Regional Grey Matter Brain Volume in Populations at Risk of Neurodegeneration.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Cerebral changes improved by physical activity during cognitive decline: A systematic review on MRI studies.NeuroImage. Clinical · 2019Pooled it
- Physical Exercise and Mechanism Related to Alzheimer's Disease: Is Gut-Brain Axis Involved?Brain sciences · 2024Review
- Effect and mechanisms of exercise for complex regional pain syndrome.Frontiers in molecular neuroscience · 2023Review
- Mechanisms of Social Interaction and Virtual Connections as Strong Predictors of Wellbeing of Older Adults.Healthcare (Basel, Switzerland) · 2022Article
- Born to move: a review on the impact of physical exercise on brain health and the evidence from human controlled trials.Arquivos de neuro-psiquiatria · 2021Review
- Does physical activity benefit motor performance and learning of upper extremity tasks in older adults? - A systematic review.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2017Review
- Comparing Aging and Fitness Effects on Brain Anatomy.Frontiers in human neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo examine whether 12 months of aerobic training (AT) moderated the relationship between change in mobility and change in basal ganglia volume than balance and toning (BAT) exercises in older adults.
designSecondary analysis of a randomized controlled trial.
settingChampaign-Urbana, Illinois.
participantsCommunity-dwelling older adults (N=101; mean age 66.4).
interventionTwelve-month exercise trial with two groups: AT and BAT. MEASUREMENTS: Mobility was assessed using the Timed Up and Go test. Basal ganglia (putamen, caudate nucleus, pallidum) was segmented from T1-weighted magnetic resonance images using the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain Software Library Integrated Registration and Segmentation Tool. Measurements were obtained at baseline and trial completion. Hierarchical multiple regression was conducted to examine whether exercise mode moderates the relationship between change in mobility and change in basal ganglia volume over 12 months. Age, sex, and education were included as covariates.
resultsExercise significantly moderated the relationship between change in mobility and change in left putamen volume. Specifically, for the AT group, volume of the left putamen did not change, regardless of change in mobility. Similarly, in the BAT group, those who improved their mobility most over 12 months had no change in left putamen volume, although left putamen volume of those who declined in mobility levels decreased significantly.
conclusionThe primary finding that older adults who engaged in 12 months of BAT training and improved mobility exhibited maintenance of brain volume in an important region responsible for motor control provides compelling evidence that such exercises can contribute to the promotion of functional independence and healthy aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.