Evidence map›Paper›PMID 26782852›Full record

Trial reportJournal of the American Geriatrics Society2016

Effects of a High-Intensity Functional Exercise Program on Dependence in Activities of Daily Living and Balance in Older Adults with Dementia.

Annika Toots, Håkan Littbrand, Nina Lindelöf, Robert Wiklund, Henrik Holmberg, Peter Nordström, Lillemor Lundin-Olsson, Yngve Gustafson, Erik Rosendahl

2 registry-linked trialsOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Geriatrics Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 69 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 9 pooled it
39.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04221724 nacompletednot on this mapstarted 2019, after this paper: background citation

A Multicomponent Physical Exercise Program: a Tool to Maintain Autonomy, Reduce Frailty and Improve Functionality in Nursing Homes. Interventional Single Group Study

TypeinterventionalSponsorUniversity of the Basque Country (UPV/EHU)Ran2019 to 2020Enrolled207ConditionsActivities of Daily Living, Frailty, Older Adults, Long Term CareArmsMulticomponent physical exercise program
NCT05877196 narecruitingnot on this mapstarted 2023, after this paper: background citation

Precision Medicine in Alzheimer's Disease: A SMART Trial of Adaptive Exercises and Their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic-Fitness Responses (The FIT-AD SMART Trial)

TypeinterventionalSponsorArizona State UniversityRan2023 to 2028Enrolled216ConditionsMild Cognitive Impairment, Alzheimer Disease, Cognitive Impairment, Cognitive DeclineArmsModerate Intensity Continuous Training (MICT), Chair-based Stretch, High-Intensity Interval Training (HIIT), Combined Aerobic Resistance Exercise (CARE)
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 9 syntheses or guidelines pooled it, 151 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Interventions for preventing falls in older people in care facilities.The Cochrane database of systematic reviews · 2025
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Annika TootsDepartment of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
Håkan LittbrandDepartment of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
Nina LindelöfDepartment of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
Robert WiklundDepartment of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
Henrik HolmbergDepartment of Community Medicine and Rehabilitation, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Peter NordströmDepartment of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.
Lillemor Lundin-OlssonDepartment of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
Yngve GustafsonDepartment of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.
Erik RosendahlDepartment of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
Umeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the effects of a high-intensity functional exercise program on independence in activities of daily living (ADLs) and balance in older people with dementia and whether exercise effects differed between dementia types.

designCluster-randomized controlled trial: Umeå Dementia and Exercise (UMDEX) study.

settingResidential care facilities, Umeå, Sweden.

participantsIndividuals aged 65 and older with a dementia diagnosis, a Mini-Mental State Examination score of 10 or greater, and dependence in ADLs (N=186).

interventionNinety-three participants each were allocated to the high-intensity functional exercise program, comprising lower limb strength and balance exercises, and 93 to a seated control activity. MEASUREMENTS: Blinded assessors measured ADL independence using the Functional Independence Measure (FIM) and Barthel Index (BI) and balance using the Berg Balance Scale (BBS) at baseline and 4 (directly after intervention completion) and 7 months.

resultsLinear mixed models showed no between-group effect on ADL independence at 4 (FIM=1.3, 95% confidence interval (CI)=-1.6-4.3; BI=0.6, 95% CI=-0.2-1.4) or 7 (FIM=0.8, 95% CI=-2.2-3.8; BI=0.6, 95% CI=-0.3-1.4) months. A significant between-group effect on balance favoring exercise was observed at 4 months (BBS=4.2, 95% CI=1.8-6.6). In interaction analyses, exercise effects differed significantly between dementia types. Positive between-group exercise effects were found in participants with non-Alzheimer's dementia according to the FIM at 7 months and BI and BBS at 4 and 7 months.

conclusionIn older people with mild to moderate dementia living in residential care facilities, a 4-month high-intensity functional exercise program appears to slow decline in ADL independence and improve balance, albeit only in participants with non-Alzheimer's dementia.

Indexed as

Activities of Daily LivingAgedAged, 80 and overDementiaExerciseExercise TherapyFemaleFollow-Up StudiesHumansMaleMotor ActivityPostural BalanceTime FactorsTreatment Outcomeactivities of daily livingdementiaexercisepostural balanceresidential facilities

Identifiers

PMID26782852
PMCPMC4722852
OpenAlexW2285371909

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.