ReviewNature reviews. Neurology2016
Randomized trials of endovascular therapy for stroke--impact on stroke care.
Review in Nature reviews. Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Trial
- Trial
- Selecting Patients for Intra-Arterial Therapy in the Context of a Clinical Trial for Neuroprotection.Stroke · 2016Trial
- Feasibility and Reliability of a Novel Tele-stroke Care Unit System in a Japanese Hospital.Neurologia medico-chirurgica · 2025Article
- Reperfusion Therapies and Post-Stroke Seizures: Evidence, Mechanisms and Clinical Implications-A Narrative Review.The Malaysian journal of medical sciences : MJMS · 2025Review
- Bilateral Oculomotor Nerve Palsy: A Rare Complication of Bridging Thrombolysis for Acute Basilar Artery Occlusion.International medical case reports journal · 2025Article
- Rapid molecular imaging of active thrombiMolecular therapy. Nucleic acids · 2023Article
- Endovascular thrombectomy for acute ischemic stroke in elderly patients with atrial fibrillation.BMC neurology · 2022Article
- Macrophage Infiltration Reduces Neurodegeneration and Improves Stroke Recovery after Delayed Recanalization in Rats.Oxidative medicine and cellular longevity · 2022Article
- Ten Years and Counting: a Celebration of the 10th Anniversary of Translational Stroke Research.Translational stroke research · 2021Article
- Optogenetic Stimulation Reduces Neuronal Nitric Oxide Synthase Expression After Stroke.Translational stroke research · 2021Article
- Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.Circulation · 2021Article
- Safety and Efficacy of Endovascular Treatment for Progressive Stroke in Patients With Acute Basilar Artery Occlusion.Frontiers in neurology · 2021Article
- Neuroprotective effects of miR-532-5p against ischemic stroke.Metabolic brain disease · 2020Article
- Course of Social Participation in the First 2 Years After Stroke and Its Associations With Demographic and Stroke-Related Factors.Neurorehabilitation and neural repair · 2018Article
- Brain and spinal cord injury repair by implantation of human neural progenitor cells seeded onto polymer scaffolds.Experimental & molecular medicine · 2018Article
- Review
- Reperfusion therapy in acute ischemic stroke: dawn of a new era?BMC neurology · 2018Review
- A Quantitative Comparison of Clinically Employed Parameters in the Assessment of Acute Cerebral Ischemia Using Dynamic Susceptibility Contrast Magnetic Resonance Imaging.Frontiers in physiology · 2018Article
- Aerobic exercise prevents rarefaction of pial collaterals and increased stroke severity that occur with aging.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Five trials that investigated the efficacy of modern endovascular therapies for stroke--MR CLEAN, ESCAPE, SWIFT PRIME, EXTEND IA and REVASCAT--have been published within the past year, changing the landscape of acute stroke management. The trials used a variety of imaging modalities and combinations of treatment approaches, including the mandatory use of intravenous thrombolysis before the initiation of endovascular therapy. All five trials provided strong evidence to support the use of thrombectomy that is initiated within 6 h of stroke onset, prompting worldwide changes in the guidelines for management of acute stroke by endovascular treatment. The benefits of endovascular therapy were observed irrespective of a patient's age, their NIH Stroke Scale score, or whether they received intravenous thrombolysis. In this article, we review the main findings of these recent trials, focusing on key aspects of their designs, and discuss their impact on the future management of patients with acute stroke that results from large-vessel occlusion. We discuss the values of noncontrast CT ASPECTS, perfusion imaging and angiography for selecting patients to receive endovascular interventions. We also consider the role of thrombectomy beyond 6 h after stroke onset, and in patients with posterior circulation strokes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.