Evidence map›Paper›PMID 26782249›Full record

ArticleAdvances in experimental medicine and biology2016

Neurovascular Interactions in the Neurologically Compromised Neonatal Brain.

H Singh, R Cooper, C W Lee, L Dempsey, S Brigadoi, A Edwards, D Airantzis, N Everdell, A Michell, D Holder and 2 more

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

H SinghneoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK. harsimrat.singh@ucl.ac.uk.
R CooperneoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.
C W LeeneoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.
L DempseyneoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.
S BrigadoineoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.
A EdwardsneoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.
D AirantzisneoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.
N EverdellneoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.
A MichellneoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.
D HolderneoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.
T AustinneoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.
J HebdenneoLAB, The Evelyn Perinatal Imaging Centre, Rosie Hospital, Cambridge, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurological brain injuries such as hypoxic ischaemic encephalopathy (HIE) and associated conditions such as seizures have been associated with poor developmental outcome in neonates. Our limited knowledge of the neurological and cerebrovascular processes underlying seizures limits their diagnosis and timely treatment. Diffuse optical tomography (DOT) provides haemodynamic information in the form of changes in concentration of de/oxygenated haemoglobin, which can improve our understanding of seizures and the relationship between neural and vascular processes. Using simultaneous EEG-DOT, we observed distinct haemodynamic changes which are temporally correlated with electrographic seizures. Here, we present DOT-EEG data from two neonates clinically diagnosed as HIE. Our results highlight the wealth of mutually-informative data that can be obtained using DOT-EEG techniques to understand neurovascular coupling in HIE neonates.

Indexed as

BrainElectroencephalographyFemaleHemodynamicsHumansHypoxia-Ischemia, BrainInfant, NewbornMaleSeizuresTomography, OpticalBurst suppressionDiffuse optical tomographyHypoxic–ischaemic encephalopathyNeonatal seizuresNeurovascular coupling

Identifiers

PMID26782249

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.