Evidence map›Paper›PMID 26782201›Full record

ArticleAdvances in experimental medicine and biology2016

The Pathway for Oxygen: Tutorial Modelling on Oxygen Transport from Air to Mitochondrion: The Pathway for Oxygen.

James B Bassingthwaighte, Gary M Raymond, Ranjan K Dash, Daniel A Beard, Margaret Nolan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Human lungs fluid mechanics: an overview of current modelling techniques.The European physical journal. E, Soft matter · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

James B BassingthwaighteDepartment of Bioengineering, University of Washington, Seattle, WA, USA. Jbb2@uw.edu.
Gary M RaymondDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Ranjan K DashDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA.
Daniel A BeardDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Margaret NolanDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA.
University of Washington · USMedical College of Wisconsin · USUniversity of Michigan–Ann Arbor · USUniversity of Pennsylvania · US

Funding

3D IMAGING &COMPUTER MODEL OF THE RESPIRATORY TRACTR01HL073598 · NHLBI · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI CORLEY, RICHARD A · 2004 to 2014
$17.6M
The Virtual Physiological Rat ProjectP50GM094503 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BEARD, DANIEL A · 2011 to 2015
$11.6M
Integrated Modeling of Cardiac Metabolism and TransportR01HL072011 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BEARD, DANIEL A · 2004 to 2016
$4.0M
Analyzing the Cardiac Power Grid: Adaptive responses to fluctuating local demandU01HL122199 · NHLBI · UNIVERSITY OF WASHINGTON · PI BEARD, DANIEL A, DASH, RANJAN K · 2015 to 2019
$3.3M
Simulation Resource in Circulatory Mass TransportR01EB001973 · NIBIB · UNIVERSITY OF WASHINGTON · PI BASSINGTHWAIGHTE, JAMES B · 2003 to 2006
$1.8M
Software Integration between JSim and Systems Biology WorkbenchR01EB008407 · NIBIB · UNIVERSITY OF WASHINGTON · PI BASSINGTHWAIGHTE, JAMES B, SAURO, HERBERT M. · 2009 to 2012
$1.3M
CARDIOVASCULAR BIOENGINEERING TRAININGT32HL007403 · NHLBI · UNIVERSITY OF WASHINGTON · PI BASSINGTHWAIGHTE, JAMES B · 1985 to 2002
$474k
FDA HHS BE-01973NHLBI NIH HHS HL 073598NHLBI NIH HHS R01 HL072011NHLBI NIH HHS R01 HL073598NHLBI NIH HHS T32 HL007403NHLBI NIH HHS U01 HL122199NIBIB NIH HHS R01 EB001973NIBIB NIH HHS R01 EB008407NIGMS NIH HHS GM094503NIGMS NIH HHS P50 GM094503
6 · The paper itself

Abstract

The 'Pathway for Oxygen' is captured in a set of models describing quantitative relationships between fluxes and driving forces for the flux of oxygen from the external air source to the mitochondrial sink at cytochrome oxidase. The intervening processes involve convection, membrane permeation, diffusion of free and heme-bound O2 and enzymatic reactions. While this system's basic elements are simple: ventilation, alveolar gas exchange with blood, circulation of the blood, perfusion of an organ, uptake by tissue, and consumption by chemical reaction, integration of these pieces quickly becomes complex. This complexity led us to construct a tutorial on the ideas and principles; these first PathwayO2 models are simple but quantitative and cover: (1) a 'one-alveolus lung' with airway resistance, lung volume compliance, (2) bidirectional transport of solute gasses like O2 and CO2, (3) gas exchange between alveolar air and lung capillary blood, (4) gas solubility in blood, and circulation of blood through the capillary syncytium and back to the lung, and (5) blood-tissue gas exchange in capillaries. These open-source models are at Physiome.org and provide background for the many respiratory models there.

Indexed as

Biological TransportHumansLungMitochondriaModels, BiologicalOxygenOxygenBlood-tissue oxygen exchangeMechanics of ventilationOxidative phosphorylationOxygen transport in blood

Identifiers

PMID26782201
PMCPMC4828238
OpenAlexW2577653522

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.