ArticleScientific reports2016
PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza viruses.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 1 of them a synthesis that pooled it.
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Who cites it
112 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Rule-based meta-analysis reveals the major role of PB2 in influencing influenza A virus virulence in mice.BMC genomics · 2019Pooled it
- Global evolutionary landscape of H11 avian influenza and initial isolates identified in Xinjiang, China.Emerging microbes & infections · 2026Article
- Article
- Molecular characterization and pathogenicity of H9N2 avian influenza viruses in poultry in Shandong Province, China, 2021-2023.Poultry science · 2026Article
- Genetic and Pathogenicity Studies of Avian Influenza (H9N2) Virus Isolated from Chickens in Jiangsu Province, China, in 2025.Microorganisms · 2026Article
- Genetic and biological characterization of H9N2 avian influenza viruses isolated from swine in China.BMC veterinary research · 2026Article
- Case Report: Detection and characterization of avian influenza virus H9N2 in a broiler farm in Mozambique, 2025.Frontiers in veterinary science · 2026Article
- Phylogenetic Analyses and Biological Characterization of H9N2 Avian Influenza Virus Isolated from Chickens in China from 2022 to 2023.Microorganisms · 2025Article
- The potential of H5N1 viruses to adapt to bovine cells varies throughout evolution.Nature communications · 2025Article
- Divergent Avian Influenza H10 Viruses from Sympatric Waterbird Species in Italy: Zoonotic Potential Assessment by Molecular Markers.Microorganisms · 2025Article
- An emerging PB2-627 polymorphism increases the zoonotic risk of avian influenza virus by overcoming ANP32 host restriction in mammalian and avian hosts.Journal of virology · 2025Article
- Pathogenicity, transmissibility, and receptor binding of a human-isolated influenza A (H10N5) virus.mBio · 2025Article
- Detection and characterization of avian influenza H9N2 in a broiler farm in mauritania; 2024.Veterinary research communications · 2025Article
- Transmission and pathogenicity in ferrets after experimental infection with HPAI clade 2.3.4.4b H5N1 viruses.The Journal of general virology · 2025Article
- Avian influenza overview March-June 2025.EFSA journal. European Food Safety Authority · 2025Article
- Exploring Avian Influenza Viruses in Yakutia-The Largest Breeding Habitat of Wild Migratory Birds in Northeastern Siberia.Viruses · 2025Article
- Genomic surveillance of influenza A virus in live bird markets during the COVID-19 pandemic.Veterinary world · 2025Article
- Experimental Infection of Rats with Influenza A Viruses: Implications for Murine Rodents in Influenza A Virus Ecology.Viruses · 2025Article
- Genetic and Molecular Characterization of Avian Influenza A(H9N2) Viruses from Live Bird Markets (LBM) in Senegal.Viruses · 2025Article
- Diversity of the H9N2 Avian Influenza Virus in Shandong Province, China.Transboundary and emerging diseases · 2025Article
52 more citing papers are in PubMed but not listed here.
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18 authors.
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Abstract
Human infections with avian influenza H7N9 or H10N8 viruses have been reported in China, raising concerns that they might cause human epidemics and pandemics. However, how these viruses adapt to mammalian hosts is unclear. Here we show that besides the commonly recognized viral polymerase subunit PB2 residue 627 K, other residues including 87E, 292 V, 340 K, 588 V, 648 V, and 676 M in PB2 also play critical roles in mammalian adaptation of the H10N8 virus. The avian-origin H10N8, H7N9, and H9N2 viruses harboring PB2-588 V exhibited higher polymerase activity, more efficient replication in mammalian and avian cells, and higher virulence in mice when compared to viruses with PB2-588 A. Analyses of available PB2 sequences showed that the proportion of avian H9N2 or human H7N9 influenza isolates bearing PB2-588 V has increased significantly since 2013. Taken together, our results suggest that the substitution PB2-A588V may be a new strategy for an avian influenza virus to adapt mammalian hosts.
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