ArticleMolecular psychiatry2016
Dopamine D2 receptors gate generalization of conditioned threat responses through mTORC1 signaling in the extended amygdala.
Article in Molecular psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.
- Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder.Molecular psychiatry · 2026Pooled it
- Amisulpride and l-DOPA modulate subcortical brain nuclei connectivity in resting-state pharmacologic magnetic resonance imaging.Human brain mapping · 2020Trial
- Alcohol abstinence precipitates alcohol seeking and aversion-resistant intake in association with increased BNST activity.Molecular psychiatry · 2026Article
- Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.Translational psychiatry · 2026Review
- A neural circuit basis for reward-induced suppression of fear generalization and enhancement of fear extinction.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A novel cost-benefit decision-making task involving cued punishment: Effects of sex and psychostimulant administration.Behavioural brain research · 2025Article
- Synaptic Plasticity of D1 and D2 Types of Neurons in the Central Amygdala After Sucrose and Cocaine Exposure.The European journal of neuroscience · 2025Article
- Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state.eLife · 2025Article
- Inhibitory effects of dopamine agonists on pain-responsive neurons in the central nucleus of the amygdala.Journal of neurophysiology · 2025Article
- Article
- Adolescent social anxiety is associated with diminished discrimination of anticipated threat and safety in the bed nucleus of the stria terminalis.Journal of psychopathology and clinical science · 2025Article
- A dopamine-dependent mechanism for Reward-induced modification of Fear memories.bioRxiv : the preprint server for biology · 2024Article
- No evidence that post-training dopamine D2 receptor agonism affects fear generalization in male rats.Journal of psychopharmacology (Oxford, England) · 2024Article
- Dopamine D2 receptors in the bed nucleus of the stria terminalis modulate alcohol-related behaviors.Addiction neuroscience · 2024Article
- Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning.Nature communications · 2023Article
- Adenosine ATranslational psychiatry · 2023Article
- Early life stress, prenatal secondhand smoke exposure, and the development of internalizing symptoms across childhood.Environmental health : a global access science source · 2023Article
- Closed-loop brain stimulation augments fear extinction in male rats.Nature communications · 2023Article
- Article
- Dopaminergic innervation at the central nucleus of the amygdala reveals distinct topographically segregated regions.Brain structure & function · 2023Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Overgeneralization of conditioned threat responses is a robust clinical marker of anxiety disorders. In overgeneralization, responses that are appropriate to threat-predicting cues are evoked by perceptually similar safety-predicting cues. Inappropriate learning of conditioned threat responses may thus form an etiological basis for anxiety disorders. The role of dopamine (DA) in memory encoding is well established. Indeed by signaling salience and valence, DA is thought to facilitate discriminative learning between stimuli representing safety or threat. However, the neuroanatomical and biochemical substrates through which DA modulates overgeneralization of threat responses remain poorly understood. Here we report that the modulation of DA D2 receptor (D2R) signaling bidirectionally regulates the consolidation of fear responses. While the blockade of D2R induces generalized threat responses, its stimulation facilitates discriminative learning between stimuli representing safety or threat. Moreover, we show that controlled threat generalization requires the coordinated activation of D2R in the bed nucleus of the stria terminalis and the central amygdala. Finally, we identify the mTORC1 cascade activation as an important molecular event by which D2R mediates its effects. These data reveal that D2R signaling in the extended amygdala constitutes an important checkpoint through which DA participates in the control of threat processing and the emergence of overgeneralized threat responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.