Evidence map›Paper›PMID 26782047›Full record

ArticleProbiotics and antimicrobial proteins2012

Cyto-Insectotoxin 1a from Lachesana tarabaevi Spider Venom Inhibits Chlamydia trachomatis Infection.

Nadezhda F Polina, Marina M Shkarupeta, Anna S Popenko, Alexander A Vassilevski, Sergey A Kozlov, Eugene V Grishin, Vassili N Lazarev, Vadim M Govorun

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nadezhda F PolinaResearch Institute for Physico-Chemical Medicine of the Federal Medical-Biological Agency of Russian Federation, 1a Malaya Pirogovskaya st., 119435, Moscow, Russia.
Marina M ShkarupetaResearch Institute for Physico-Chemical Medicine of the Federal Medical-Biological Agency of Russian Federation, 1a Malaya Pirogovskaya st., 119435, Moscow, Russia.
Anna S PopenkoResearch Institute for Physico-Chemical Medicine of the Federal Medical-Biological Agency of Russian Federation, 1a Malaya Pirogovskaya st., 119435, Moscow, Russia.
Alexander A VassilevskiShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya st., 117997, Moscow, Russia.
Sergey A KozlovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya st., 117997, Moscow, Russia.
Eugene V GrishinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya st., 117997, Moscow, Russia.
Vassili N LazarevResearch Institute for Physico-Chemical Medicine of the Federal Medical-Biological Agency of Russian Federation, 1a Malaya Pirogovskaya st., 119435, Moscow, Russia. lazar0@mail.ru.
Vadim M GovorunResearch Institute for Physico-Chemical Medicine of the Federal Medical-Biological Agency of Russian Federation, 1a Malaya Pirogovskaya st., 119435, Moscow, Russia.
Federal Medical-Biological Agency · RUInstitute of Bioorganic Chemistry · RUKurchatov Institute · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Venom of the ant spider Lachesana tarabaevi contains a wide variety of antimicrobial peptides. Among them, a special place belongs to cyto-insectotoxins, a class of cytolytic molecules showing equally potent antimicrobial and insecticidal effects. We tested one of them, CIT 1a, for ability to suppress Chlamydia trachomatis infection. HEK293 cells were transfected with plasmid vectors harboring the cit 1a gene. Controlled expression of the transgene led to a significant decrease in C. trachomatis viability inside the infected cells. Using proteomic and transcriptomic approaches, we found alterations in protein expression patterns and identified differentially expressed genes in transfected cells.

Indexed as

Antimicrobial peptideCytolytic peptideGene therapyInfectious diseaseProteomicsTranscriptome

Identifiers

PMID26782047
OpenAlexW2013256817

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.